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References
Aivazian D, Stern LJ. Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition. Nat Struct Biol. 2000;7(11):1023–6.
Baniyash M. TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response. Nat Rev Immunol. 2004;4(9):675–87.
Borroto A, Abia D, et al. Crammed signaling motifs in the T-cell receptor. Immunol Lett. 2014;161(1):113–7.
Call ME, Schnell JR, et al. The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell. 2006;127(2):355–68.
Curnow SJ, Boyer C, et al. TCR-associated zeta-Fc epsilon RI gamma heterodimers on CD4-CD8- NK1.1+ T cells selected by specific class I MHC antigen. Immunity. 1995;3(4):427–38.
Dai H, Wang Y, et al. Chimeric antigen receptors modified T-cells for cancer therapy. J Natl Cancer Inst. 2016;108(7). https://doi.org/10.1093/jnci/djv439.
Delgado P, Cubelos B, Calleja E, Martínez-Martín N, Ciprés A, Mérida I, Bellas C, Bustelo XR, Alarcón B. Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Nat Immunol. 2009;10(8):880–8.
Deng GM, Beltran J, et al. T cell CD3ζ deficiency enables multiorgan tissue inflammation. J Immunol. 2013;191(7):3563–7.
D’Oro U, Munitic I, Chacko G, Karpova T, McNally J, Ashwell JD. Regulation of constitutive TCR internalization by the zeta-chain. J Immunol. 2002;169(11):6269–78.
Eleftheriadis T, Kartsios C, et al. Chronic inflammation and CD16+ natural killer cell zeta-chain downregulation in hemodialysis patients. Blood Purif. 2008;26(4):317–21.
Fernández-Arenas E, Calleja E, Martínez-Martín N, Gharbi SI, Navajas R, García-Medel N, Penela P, Alcamí A, Mayor F Jr, Albar JP, Alarcón B. β-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism. EMBO J. 2014 Mar;33(6):559–77.
Gagnon E, Schubert DA, et al. Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain. J Exp Med. 2012;209(13):2423–39.
Hayes SM, Love PE. Distinct structure and signaling potential of the gamma delta TCR complex. Immunity. 2002;16(6):827–38.
Holst J, Wang H, et al. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nat Immunol. 2008;9(6):658–66.
Kersh EN, Shaw AS, et al. Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation. Science. 1998;281(5376):572–5.
Lanier LL, Yu G, et al. Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells. Nature. 1989;342(6251):803–5.
Lee MS, Glassman CR, et al. A mechanical switch couples T cell receptor triggering to the cytoplasmic juxtamembrane regions of CD3ζζ. Immunity. 2015;43(2):227–39.
Louveau A, Angibaud J, et al. Impaired spatial memory in mice lacking CD3ζ is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency. J Neurosci. 2013;33(47):18672–85.
Malissen B. An evolutionary and structural perspective on T cell antigen receptor function. Immunol Rev. 2003;191:7–191.
Malissen M, Gillet A, et al. T cell development in mice lacking the CD3-zeta/eta gene. EMBO J. 1993;12(11):4347–55.
Martín-Cófreces NB, Baixauli F, López MJ, Gil D, Monjas A, Alarcón B, Sánchez-Madrid F. End-binding protein 1 controls signal propagation from the T cell receptor. EMBO J. 2012 Nov;31(21):4140–52.
Minguet S, Schamel WWA. A permissive geometry model for TCR-CD3 activation. Trends Biochem Sci. 2008;33(2):51–7.
Minguet S, Swamy M, et al. The short length of the extracellular domain of zeta is crucial for T cell antigen receptor function. Immunol Lett. 2008;116(2):195–202.
Molnár E, Swamy M, et al. Cholesterol and sphingomyelin drive ligand-independent T-cell antigen receptor nanoclustering. J Biol Chem. 2012;287(51):42664–74.
Nambiar MP, Enyedy EJ, et al. Polymorphisms/mutations of TCR-zeta-chain promoter and 3′ untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3′ untranslated region in patients with systemic lupus erythematosus. J Autoimmun. 2001;16(2):133–42.
Ohno H, Saito T. CD3 zeta and eta chains are produced by alternative splicing from a common gene. Int Immunol. 1990;2(11):1117–9.
Ohno H, Aoe T, et al. Developmental and functional impairment of T cells in mice lacking CD3 zeta chains. EMBO J. 1993;12(11):4357–66.
Pitcher LA, Mathis MA, et al. Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR zeta promotes the emergence of T cells with autoreactive potential. J Immunol. 2005a;174(10):6071–9.
Pitcher LA, Mathis MA, et al. The CD3 gamma epsilon/delta epsilon signaling module provides normal T cell functions in the absence of the TCR zeta immunoreceptor tyrosine-based activation motifs. Eur J Immunol. 2005b;35(12):3643–54.
Proust R, Bertoglio J, et al. The adaptor protein SAP directly associates with CD3ζ chain and regulates T cell receptor signaling. PLoS One. 2012;7(8):e43200.
Rieux-Laucat F, Hivroz C, et al. Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. N Engl J Med. 2006;354(18):1913–21.
Samelson LE, Harford JB, et al. Identification of the components of the murine T cell antigen receptor complex. Cell. 1985;43(1):223–31.
Schamel WW, Alarcón B. Organization of the resting TCR in nanoscale oligomers. Immunol Rev. 2013;251(1):13–20.
Schamel WW, Arechaga I, et al. Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response. J Exp Med. 2005;202(4):493–202.
Shi X, Bi Y, et al. Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids. Nature. 2013;493(7430):111–5.
Swamy M, Beck-Garcia K, et al. A cholesterol-based allostery model of T cell receptor phosphorylation. Immunity. 2016;44(5):1091–101.
Takeuchi T, Suzuki K. CD247 variants and single-nucleotide polymorphisms observed in systemic lupus erythematosus patients. Rheumatology (Oxford). 2013;52(9):1551–5.
Takeuchi T, Tsuzaka K, et al. TCR zeta chain lacking exon 7 in two patients with systemic lupus erythematosus. Int Immunol. 1998;10(7):911–21.
Taylor DD, Sullivan SA, et al. Modulation of T-cell CD3-zeta chain expression during normal pregnancy. J Reprod Immunol. 2002;54(1–2):15–31.
van Oers NS, Tohlen B, et al. The 21- and 23-kD forms of TCR zeta are generated by specific ITAM phosphorylations. Nat Immunol. 2000;1(4):322–8.
Wang J, Yi L, et al. Lack of association of the CD247 SNP rs2056626 with systemic sclerosis in Han Chinese. Open Rheumatol J. 2014;8:43–5.
Xu HP, Chen H, et al. The immune protein CD3zeta is required for normal development of neural circuits in the retina. Neuron. 2010;65(4):503–15.
Yudushkin IA, Vale RD. Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3{zeta} in the endosomal compartment. Proc Natl Acad Sci USA. 2010;107(51):22128–33.
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Morath, A., Deswal, S., Schamel, W.W.A. (2018). CD3ζ. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_613
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