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Encyclopedia of Signaling Molecules pp 3656–3665Cite as

Opioid Receptor

  • Reference work entry
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Synonyms

From http://www.genome.jp/kegg/genes.html

μ-opioid receptor (MOP): OPRM1, KIAA0403, LMOR, MOR, MOR1, OPRM

δ-opioid receptor (DOP): OPRD1, OPRD

κ-opioid receptor (KOP): OPRK1, KOR, OPRK

Nociceptin opioid receptor (NOP): OPRL1, KOR-3, MGC34578, NOCIR, OOR, ORL1

Historical Background

The existence of opioid receptors (OR) was postulated in 1954 (Beckett and Casy 1954), at a time when evidence for specific drug-responsive substances was evasive and the concept of biochemical receptors was still in its infancy. Unequivocal confirmation of specific binding sites for opioids in the brain was first reported in 1973 (Pert and Snyder 1973; Simon et al. 1973; Terenius 1973). This breakthrough was shortly followed by evidence that opioid ligands bind specifically to different anatomical locations and show different pharmacological activity, suggesting that several types of opioid receptors exist (Martin et al. 1976; Lord et al. 1977). Based on extensive pharmacological and animal model...

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Authors and Affiliations

  1. Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institute, CMM L8:01, 17176, Stockholm, Sweden

    Vladana Vukojević, Yu Ming & Lars Terenius

  2. Department of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd., 91010, Duarte, CA, USA

    Tijana Jovanović-Talisman

Authors
  1. Vladana Vukojević
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  2. Yu Ming
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  3. Tijana Jovanović-Talisman
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  4. Lars Terenius
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Corresponding author

Correspondence to Vladana Vukojević .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Vukojević, V., Ming, Y., Jovanović-Talisman, T., Terenius, L. (2018). Opioid Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_596

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