Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Karen NolanEmail author
  • Catherine Godson
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_590


Historical Background

The FPR2/ALX receptor is a member of the formyl peptide receptor (FPR) superfamily which in humans also includes formyl peptide receptor 1 (FPR1) and formyl peptide receptor 3 (FPR3). Recent interest in this specific receptor reflects its intriguing anti-inflammatory and proresolving bioactions in contrast to other FPR family members (Serhan 2007; Maderna et al. 2010). FPR2/ALX was identified as a specific receptor for lipoxin A4 (LXA4) in 1992 (Fiore et al. 1992). Using radiolabeled [11,12-3H]LXA4 and human polymorphonuclear leukocytes (PMNs) in which LXA4-mediated action had previously been identified, specific stereoselective binding with a Kd of approximately 0.5 nM was demonstrated. Modulation of [11,12-3H]LXA4binding by guanosine analogs indicated that this binding site was a G-protein-coupled receptor...

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The authors thank Dr. Aisling Kennedy and Dr. Eoin Brennan for their helpful comments. Work in the authors’ lab is funded by Science Foundation Ireland, The Health Research Board, and The Government of Ireland Programme for Research in Third-Level Institutions. Karen Nolan is an IRCSET postgraduate Scholar.


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.UCD Diabetes Research Centre, UCD Conway InstituteSchool of Medicine and Medical Sciences, University College DublinDublinIreland