Skip to main content
SpringerLink
Log in

CLEC7A

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 182 Accesses

Synonyms

β-glucan receptor; Dectin-1

Historical Background

The existence of a macrofphage β-glucan-binding receptor had been recognized for about three decades before the identification of Dectin-1 in 2001 as the receptor for these carbohydrates (Brown and Gordon 2001). Many of the immunomodulatory properties attributed to β-glucans were previously ascribed to the Complement Receptor (CR-3, Mac-1, CD11b/CD18), which was thought to directly recognize β-glucan, among many other ligands. Although additional receptors recognizing β-glucan have been identified, such as lactosylceramide, Langerin, and the scavenger receptors CD5, CL-P1, SCARF1, and CD36, the generation of Dectin-1 knockout (KO) mice has demonstrated that β-glucan recognition by this receptor is central to the immune response to many fungal pathogens. From data generated over the past decade, it is now known that Dectin-1 has a pivotal role in the innate immune protective response to fungi, and that this receptor can induce...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adams EL, Rice PJ, Graves B, Ensley HE, Yu H, Brown GD, et al. Differential high affinity interaction of Dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side chain branching. J Pharmacol Exp Ther. 2008;325(1):115–23.

    Article  PubMed  CAS  Google Scholar 

  • Ariizumi K, Shen GL, Shikano S, Xu S, Ritter 3rd R, Kumamoto T, et al. Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem. 2000;275:20157–67.

    Article  PubMed  CAS  Google Scholar 

  • Brown GD. Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol. 2006;6(1):33–43.

    Article  PubMed  CAS  Google Scholar 

  • Brown GD. Innate antifungal immunity: the key role of phagocytes. Annu Rev Immunol. 2010;29:1–21.

    Article  CAS  Google Scholar 

  • Brown GD, Gordon S. Immune recognition: A new receptor for beta-glucans. Nature. 2001;413(6851):36–7.

    Article  PubMed  CAS  Google Scholar 

  • Brown J, O’Callaghan CA, Marshall AS, Gilbert RJ, Siebold C, Gordon S, et al. Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function. Protein Sci. 2007;16(6):1042–52.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chai LY, van de Veerdonk F, Marijnissen RJ, Cheng SC, Khoo AL, Hectors M, et al. Anti-Aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity. Immunology. 2010;130(1):46–54.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cunha C, Di Ianni M, Bozza S, Giovannini G, Zagarella S, Zelante T, et al. Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. Blood. 2010;116(24):5394–402.

    Article  PubMed  CAS  Google Scholar 

  • den Dunnen J, Gringhuis SI, Geijtenbeek TB. Dusting the sugar fingerprint: C-type lectin signaling in adaptive immunity. Immunol Lett. 2010;128(1):12–6.

    Article  CAS  Google Scholar 

  • Drummond RA, Saijo S, Iwakura Y, Brown GD. The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. Eur J Immunol. 2011;41(2):276–81.

    Article  PubMed  CAS  Google Scholar 

  • Gales A, Conduche A, Bernad J, Lefevre L, Olagnier D, Beraud M, et al. PPARgamma controls dectin-1 expression required for host antifungal defense against Candida albicans. PLoS Pathog. 2010;6(1):e1000714.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Giles SS, Dagenais TR, Botts MR, Keller NP, Hull CM. Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans. Infect Immun. 2009;77(8):3491–500.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Goodridge HS, Wolf AJ, Underhill DM. Beta-glucan recognition by the innate immune system. Immunol Rev. 2009;230(1):38–50.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Greenblatt MB, Aliprantis A, Hu B, Glimcher LH. Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med. 2010;207(5):923–31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, et al. Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat Immunol. 2009;10(2):203–13.

    Article  PubMed  CAS  Google Scholar 

  • Gross O, Poeck H, Bscheider M, Dostert C, Hannesschlager N, Endres S, et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature. 2009;459(7245):433–6.

    Article  PubMed  CAS  Google Scholar 

  • Hise AG, Tomalka J, Ganesan S, Patel K, Hall BA, Brown GD, et al. An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe. 2009;5(5):487–97.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Inoue M, Moriwaki Y, Arikawa T, Chen YH, YJ O, Oliver T, et al. Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses. J Immunol. 2011;186(1):19–23.

    Article  PubMed  CAS  Google Scholar 

  • Kankkunen P, Teirila L, Rintahaka J, Alenius H, Wolff H, Matikainen S. (1,3)-beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages. J Immunol. 2010;184(11):6335–42.

    Article  PubMed  CAS  Google Scholar 

  • Kerrigan AM, Brown GD. Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs. Immunol Rev. 2010;234(1):335–52.

    Article  PubMed  CAS  Google Scholar 

  • Kerrigan AM, Brown GD. Syk-coupled C-type lectins in immunity. Trends Immunol. 2011;32(4):151–6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Marakalala MJ, Guler R, Matika L, Murray G, Jacobs M, Brombacher F, et al. The Syk/CARD9-coupled receptor dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. Microbes Infect. 2011a;13(2):198–201.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Marakalala MJ, Kerrigan AM, Brown GD. Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans. Mamm Genome. 2011b;22(1–2):55–65.

    Article  PubMed  CAS  Google Scholar 

  • Mocsai A, Ruland J, Tybulewicz VL. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol. 2010;10(6):387–402.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nakamura K, Kinjo T, Saijo S, Miyazato A, Adachi Y, Ohno N, et al. Dectin-1 is not required for the host defense to Cryptococcus neoformans. Microbiol Immunol. 2007;51(11):1115–9.

    Article  PubMed  CAS  Google Scholar 

  • Plantinga TS, Hamza OJ, Willment JA, Ferwerda B, van de Geer NM, Verweij PE, et al. Genetic variation of innate immune genes in HIV-infected African patients with or without oropharyngeal candidiasis. J Acquir Immune Defic Syndr. 2010;55(1):87–94.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Reid DM, Gow NA, Brown GD. Pattern recognition: recent insights from dectin-1. Curr Opin Immunol. 2009;21(1):30–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rivera A, Hohl TM, Collins N, Leiner I, Gallegos A, Saijo S, et al. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med. 2011;208(2):369–81.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rosas M, Liddiard K, Kimberg M, Faro-Trindade I, McDonald JU, Williams DL, et al. The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis. J Immunol. 2008;181(5):3549–57.

    Article  PubMed  CAS  Google Scholar 

  • Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, Akitsu A, et al. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity. 2010;32(5):681–91.

    Article  PubMed  CAS  Google Scholar 

  • Takahara K, Tokieda S, Nagaoka K, Takeda T, Kimura Y, Inaba K. C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with dectin-1. Eur J Immunol. 2011. https://doi.org/10.1002/eji.200940188.

  • Vautier S, Sousa Mda G, Brown GD. C-type lectins, fungi and Th17 responses. Cytokine Growth Factor Rev. 2010;21(6):405–12.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Werner JL, Metz AE, Horn D, Schoeb TR, Hewitt MM, Schwiebert LM, et al. Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J Immunol. 2009;182(8):4938–46.

    Article  PubMed  CAS  Google Scholar 

  • Willment JA, Brown GD. Dectin-1. UCSD signaling gateway molecule pages. 2010. https://doi.org/10.1038/mp.a004078.01. http://www.signaling-gateway.org/

  • Zenaro E, Donini M, Dusi S. Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, mannose receptor, and DC-SIGN. J Leukoc Biol. 2009;86(6):1393–401.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Medical Sciences, AB25 2ZD, Aberdeen, UK

    Janet A. Willment

  2. Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, Aberdeen Fungal Group, Aberdeen Fungal Group, AB25 2ZD, Aberdeen, UK

    Gordon D. Brown

Authors
  1. Janet A. Willment
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gordon D. Brown
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Janet A. Willment .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Willment, J.A., Brown, G.D. (2018). CLEC7A. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_584

Download citation

Publish with us

Policies and ethics

Search

Navigation