Skip to main content
SpringerLink
Log in
Book cover

Encyclopedia of Signaling Molecules pp 1102–1109Cite as

Cholecystokinin-2 Receptor

  • Reference work entry
  • First Online:

  • 38 Accesses

Synonyms

The cholecystokinin-B receptor

Historical Background

With the availability of modern biochemical and molecular techniques developed in the 1980s and 1990s, it was possible to characterize and clone the two cholecystokinin receptors known today. They are now identified as the cholecystokinin-1 (CCK-1) and the cholecystokinin-2 (CCK-2) receptor subtypes.

In this review entry, we will summarize what we now know about the CCK-2 receptor. More specifically, we will discuss its biochemical characterization, its organ localization, its functions in normal organs, its role in cancer along with the intracellular signaling routes used to relay its messages. References to the other cholecystokinin receptor are given in the preceding chapter.

Biochemical Characterization

Initially, the CCK-1 receptor was known as the CCKA receptor (A for alimentary) and the CCK-2 receptor as the CCKBreceptor (B for brain). This reclassification of the CCK receptor subtypes occurred recently based on...

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Attoub S, Levasseur S, Buyse M, Goiot H, Laigneau JP, Moizo L, et al. Physiological role of cholecystokinin B/gastrin receptor in leptin secretion. Endocrinology. 1999;140:4406–10.

    Article  PubMed  CAS  Google Scholar 

  • Bakke I, Qvigstad G, Sandvik AK, Waldum HL. The CCK-2 receptor is located on the ECL cell, but not on the parietal cell. Scand J Gastroenterol. 2001;36:1128–33.

    Article  PubMed  CAS  Google Scholar 

  • Baldwin GS, Shulkes A. Gastrin, gastrin receptors and colorectal carcinoma. Gut. 1998;42(4):581.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Biagini P, Monges G, Vuarogueaux V, Parriaux D, Cantaloube JF, De Micco P. The human gastrin/cholecystokinin receptors: type B and type C expression in colonic tumors and cell lines. Life Sci. 1997;61:1009–18.

    Article  PubMed  CAS  Google Scholar 

  • Bierkamp C, Kowalski-Chauvel A, Dehez S, Fourmy D, Pradayrol L, Seva C. Gastrin mediated cholecystokinin-2 receptor activation induces loss of cell adhesion and scattering in epithelial MDCK cells. Oncogene. 2002;21:7656–70.

    Article  PubMed  CAS  Google Scholar 

  • Clerc P, Dufresne M, Saillan C, Chastre E, André T, Escrieut C, et al. Differential expression of the CCK-A and CCK-B/gastrin receptor genes in human cancers of the esophagus, stomach and colon. Int J Cancer. 1997;72(6):931.

    Article  PubMed  CAS  Google Scholar 

  • Clerc P, Leung-Theung-Long S, Wang TC, Dockray GJ, Bonisson M, Delisle MB, Vaysse N, Pradayrol L, Fourmy D, Dufresne M. Expression of CCK2 receptors in the murine pancreas: proliferation, transdifferentiation of acinar cells and neoplasia. Gastroenterology. 2002;122:428–37.

    Article  PubMed  CAS  Google Scholar 

  • Detjen K, Yule D, Tseng M-J, Williams JA, Logsdon CD. CCK-B receptors produce similar signals but have opposite growth effects in CHO and Swiss 3T3 cells. Am J Physiol. 1997;273:G1449–57.

    Article  Google Scholar 

  • Dufresne M, Seva C, Fourmy D. Cholecystokinin and gastrin receptors. Physiol Rev. 2006;86:805–47.

    Article  PubMed  CAS  Google Scholar 

  • El-Kouhen K, Morisset J. Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors’ occupation in RIN-14B cells, a rat pancreatic islet cell line. Pancreas. 2010;39:127–34.

    Article  PubMed  CAS  Google Scholar 

  • Fourmy D, Zahidi A, Pradayrol L, Vayssette J, Ribet A. Relationship of CCK/gastrin receptor binding to amylase release in dog pancreatic acini. Regul Pept. 1984;10:57–68.

    Article  PubMed  CAS  Google Scholar 

  • Haigh CR, Attwood SEA, Thompson DG, Jankowski JA, Kirton CM, Pritchard DM, et al. Gastrin induces proliferation in Barrett’s metaplasia through activation of the CCK2 receptor. Gastroenterology. 2003;124:615–25.

    Article  PubMed  CAS  Google Scholar 

  • Jagerschmidt A, Popovici T, O’Donohue M, Roques BP. Identification and characterization of various cholecystokinin B receptor mRNA forms in rat brain tissue and partial determination of the cholecystokinin B receptor gene structure. J Neurochem. 1994;63:1199–206.

    Article  PubMed  CAS  Google Scholar 

  • Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology. 2001;121:1380–90.

    Article  PubMed  CAS  Google Scholar 

  • Julien S, Lainé J, Morisset J. The rat pancreatic islets: a reliable tool to study islet responses to cholecystokinin receptor occupation. Regul Pept. 2004;121:73–81.

    Article  PubMed  CAS  Google Scholar 

  • Kinoshita Y, Nakata H, Kishi K, Kawanami C, Sawada M, Chiba T. Comparison of the signal transduction pathways activated by gastrin in enterochromaffin-like and parietal cells. Gastorenterology. 1998;115:93–100.

    Article  CAS  Google Scholar 

  • Mazzocchi G, Malendowicz LK, Aragona F, Spinazzi R, Nussdorfer GG. Cholecystokinin (CCK) stimulates aldosterone secretion from human adrenocortical cells via CCK2 receptors coupled to the adenylate cyclase/protein kinase A signaling cascade. J Clin Endocrinol Metab. 2004;89:1277–84.

    Article  PubMed  CAS  Google Scholar 

  • Morisset J. The gastrointestinal cholecystokinin receptors in health and diseases. Ann Acad Med Bialostocensis. 2005;50:21–36.

    CAS  Google Scholar 

  • Morisset J, Calvo E. Trophicity of the pancreas: from rodents to man. J Physiol Pharmacol. 1998;49(Suppl 2):25–37.

    Google Scholar 

  • Morisset J, Lainé J, Biernat M, Julien S. What are the pancreatic target cells for gastrin and its CCKB receptor? Is this a couple for cancerous cells? Med Sci Monit. 2004;10:RA 242–6.

    CAS  Google Scholar 

  • Muerkoster S, Isberner A, Arlt A, Witt M, Reimann B, Blaszezuk E, et al. Gastrin suppresses growth of CCK2 receptor expressing in colon cancer cells by inducing apoptosis in vitro and in vivo. Gastroenterology. 2005;129:952–68.

    Article  PubMed  CAS  Google Scholar 

  • Murphy JA, Criddle DN, Sherwood M, Chvanov M, Mukherjee R, McLaughlin E, et al. Direct activation of cytosolic Ca2+ signalling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology. 2008;135:632–41.

    Article  PubMed  CAS  Google Scholar 

  • Rozengurt E, Walsh JH. Gastrin, CCK, signaling, and cancer. Annu Rev Physiol. 2001;63:49–76.

    Article  PubMed  CAS  Google Scholar 

  • Saillan-Barreau C, Clerc P, Adato M, Escrieut C, Vaysse N, Fourmy D, Dufresne M. Transgenic CCK-B/gastrin receptor mediates murine exocrine pancreatic secretion. Gastroenterology. 1998;115:988–96.

    Article  PubMed  CAS  Google Scholar 

  • Scemama J, DeVries L, Pradayrol L, Seva C, Tronchere H, Vaysse N. Cholecystokinin and gastrin peptides stimulate ODC activity in a rat pancreatic cell line. Am J Physiol. 1989;256:G846–50.

    PubMed  CAS  Google Scholar 

  • Smith JP, Verderame MF, McLaughlin P, Martenis M, Ballard E, Zagon IS. Characterization of the CCK-C (cancer) receptor in human pancreactic cancer. Int J Mol Med. 2002;10:689–94.

    PubMed  CAS  Google Scholar 

  • Solomon TE, Morisset J, Wood JG, Bussjaeger LJ. Additive interaction of pentagastrin and secretin on pancreatic growth in rats. Gastroenterology. 1987;92:429–35.

    Article  PubMed  CAS  Google Scholar 

  • Takeuchi K, Johnson LR. The role of food intake on gastric mucosal growth and gastrin receptors during pregnancy and lactation. Proc Soc Exp Biol Med. 1987;186:198–204.

    Article  PubMed  CAS  Google Scholar 

  • Tarasova NI, Romanov VI, Da Pinto SP, Michejda CJ. Numerous cell targets for gastrin in the guinea pig stomach revealed by gastrin/CCKB receptor localization. Cell Tissue Res. 1996;283:1–6.

    Article  PubMed  CAS  Google Scholar 

  • Tommeras K, Hammer P, Sundler F, Borch K, Mardh S, Cabero JL. Immunolocalization of cholecystokinin-2 receptors in rat gastric mucosa. Scand J Gastroenterol. 2002;37:1017–24.

    Article  PubMed  CAS  Google Scholar 

  • Waki S, Kinoshita Y, Wang H-Y, Asahara M, Matsushima Y, Sazzad Hassan MD, et al. Effect of aging on gastrin receptor gene expression in rat stomach. Peptides. 1998;19:225–9.

    Article  PubMed  CAS  Google Scholar 

  • Yu DH, Noguchi M, Zhou ZC, Villanueva ML, Gardner JD, Jensen RT. Characterization of gastrin receptors on guinea pig pancreatic acini. Am J Physiol. 1987;253:G793–801.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service de gastroentérologie, Département de médecine, Université de Sherbrooke, J1H 5N4, Sherbrooke, QC, Canada

    Jean Morisset

Authors
  1. Jean Morisset
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jean Morisset .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Morisset, J. (2018). Cholecystokinin-2 Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_582

Download citation

Publish with us

Policies and ethics

Search

Navigation