CCL5 was initially described in 1988 and this new protein was named for its characteristics: Regulated upon Activation expressed by Normal T cells and presumably Secreted (RANTES) (Schall et al. 1988). A relatively new technology, at the time, was used to identify RANTES, subtraction cDNA libraries, which help to distinguish genes expressed in one cell and not in another. This genetic approach has since led to the uncovering of about 50 other chemokines, and in order to clarify the nomenclature of all chemokines and their receptors, a new nomenclature has been introduced, in which RANTES has been renamed CCL5 (Zlotnik and Yoshie 2000). CCL5 was first discovered in T cell-specific cDNA, and this initial report on CCL5 placed further attention on a new family of chemotactic proteins that proved to be important in influencing a series of biologic and pathological processes (Levy 2009).
Collectively, chemokines are defined as small (8–14 kDa) proteins...
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