Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Slp (Synaptotagmin-Like Protein)

  • Mitsunori Fukuda
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_560

Synonyms

Historical Background

Synaptotagmin-like proteins (Slps) were originally identified as synaptotagmin-related molecules containing two C2 calcium/phospholipid-binding motifs (named the C2A domain and the C2B domain) at their C terminus and no transmembrane domain at their N terminus (Fig. 1a), which suggested that they regulate certain intracellular membrane traffic events, the same as synaptotagmin I (Syt I) does in synaptic vesicle traffic (Fukuda and Mikoshiba 2001). The Slp family of proteins is now defined as a family of proteins, each of which contains an N-terminal conserved motif named the Slp homology domain (SHD) (Fig. 1a, magenta boxes) and C-terminal tandem C2 domains, although some members of the Slp family have several isoforms (e.g., Slp2-b, Slp3-b, and Slp4-b) that lack one of these domains because of alternative splicing (Fig. 1a, bars and arrows) (Fukuda et al. 2001). The Slp family is also recognized as the third group...
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and NeurosciencesGraduate School of Life Sciences, Tohoku UniversitySendaiJapan