Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

CCN

  • Satoshi Kubota
  • Masaharu Takigawa
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_559

Synonyms

Historical Background

In the early 1990s, three gene products with novel structural similarity were identified. The first member was discovered as a factor induced upon growth factor stimulation and was designated as cysteine-rich 61 (Cyr61), based on its structural characteristics. The second member was purified as a platelet growth factor-related molecule with a mitogenic effect on fibroblasts and thus, it was initially named connective tissue growth factor (CTGF). Subsequently, a gene with structural similarity to the above two genes was found to be overexpressed in nephroblastomas, which provided the name nephroblastoma-overexpressed (NOV) gene to this third member. Based on these findings, the acronym of the names of these three genes,...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular DentistryOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayamaJapan
  2. 2.Advanced Research Center for Oral and Craniofacial SciencesOkayama University Dental School/Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayamaJapan