Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Integrin α1 (ITGA1)

  • Jyrki Heino
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_556

Synonyms

Historical Background

Integrin α1 subunit forms a heterodimer with integrin β1 subunit and acts as a cellular collagen receptor. α1β1 is one of the first integrins found, and it was originally described as T lymphocyte very late activation antigen-1 (VLA-1). Today the human integrin family is known to contain 24 α/β heterodimers that mediate adhesion to extracellular matrix (ECM), plasma proteins, or counter receptors on other cells. The cytoplasmic domains of integrin α and β subunits are connected to cytoskeletal filaments and also to multiple cellular signaling pathways (Hynes 2004).

Structure

Integrins are single-pass type I membrane glycoproteins. Integrin α1 subunit contains short intracellular domain, transmembrane anchor, and an extracellular part, composed of α1I, β-propeller, thigh, calf-1, and calf-2 domains (Fig. 1). Thus, α1 belongs to a subgroup of integrins that contain an αI domain (inserted domain that is often...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of TurkuTurkuFinland