In 1998, ZNF202 was initially cloned and described as testis-specific zinc finger transcription factor (Monaco et al. 1998). Two years later, in 2000, a linkage analysis in Utah pedigrees suffering from hypoalphalipoproteinemia could identify a new low HDL locus on chromosome 11q23 distinct from the apolipoprotein AI/CIII/AIV/AV gene cluster (Kort et al. 2000). In addition to low HDL cholesterol, family members very frequently exhibited early onset of coronary heart disease (Kort et al. 2000). The newly identified locus contains the gene of the zinc finger transcription factor ZNF202 (Monaco et al. 1998; Wagner et al. 2000). A bioinformatics approach screening for ZNF202 transcription factor binding sites revealed that the ZNF202 gene product is a transcriptional repressor that binds to elements found predominantly in genes that either participate in lipid metabolism or being involved in processes related to energy...
This work was supported by EU Framework 7 project “LipidomicNet”.
- Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, et al. The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. J Biol Chem. 2001;276(15):12427–33.CrossRefPubMedGoogle Scholar