The serine/threonine protein kinase D (PKD) was first described in 1994. Due to some homology in its kinase domain, its ability to bind the lipid diacylglycerol (DAG), and its responsiveness to phorbol ester, PKD was originally classified as a member of the protein kinase C (PKC) family (Johannes et al. 1994). Later, it became evident that PKD represents an own group of kinases more closely related to the calcium/calmodulin-regulated (Cam) kinases (Manning et al. 2002). Initially, the PKD field focused on determining the functions of the structural elements and domains of PKD1 as well as the activation mechanisms for this kinase. With the identification of the PKD phosphorylation motif (Hutti et al. 2004) and the subsequent generation of a substrate-specific antibody (Döppler et al. 2005), optimal conditions were provided for the discovery of PKD substrates. This led to an increasing wealth of...
- Borges S, Döppler H, Perez EA, Andorfer CA, Sun Z, Anastasiadis PZ, Thompson EA, Geiger XJ, Storz P. Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis. Breast Cancer Res. 2013;15(2):R66. http://www.ncbi.nlm.nih.gov/pubmed/23971832
- Liou GY, Döppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun. 2015;6:6200. http://www.ncbi.nlm.nih.gov/pubmed/25698580
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