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Mapkap Kinase 2/3 (MK2/3)

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

Hsp25-kinase; Hsp27-kinase; Hspb1-kinase; MAPKAP kinase 2/3; MAPKAPK 2/3; sHsp-kinase

Historical Background

Formally, all protein kinases downstream to MAP kinases should be regarded as MAPK-activated protein kinases (MKs). This would include ribosomal S6-kinases (RSKs); mitogen- and stress-activated protein kinases (MSKs); MAP kinase-interacting kinases (MNKs); as well as MK2, MK3, and MK5/PRAK (Roux and Blenis 2004). However, due to the specificity of activation, this group of protein kinases is further subdivided (Fig. 1): RSKs are activated by classical ERKs (Erk1/Erk2) and MSKs and MNKs are phosphorylated by both ERKs and p38 MAPK. MK2 and MK3 are the only MKs which are exclusively activated by p38 MAPK. MK5/PRAK has been described as a “p38-regulated and -activated kinase (PRAK),” but its activation by p38 MAPK is challenged, and alternative activation by atypical MAPKs (Erk3/Erk4) is discussed (Gaestel 2006). For historical reasons RSK was designated MAPKAPK 1 (MK1),...

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Authors and Affiliations

  1. Hannover Medical School, Institute of Cell Biochemistry, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Matthias Gaestel

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  1. Matthias Gaestel
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Correspondence to Matthias Gaestel .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Gaestel, M. (2018). Mapkap Kinase 2/3 (MK2/3). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_531

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