CD43, also called sialophorin or leukosialin, was first identified as a defective molecule of leukocytes and platelets of patients affected with the Wiskott–Aldrich syndrome, yet the molecule responsible for this immunodeficiency turned out to be WASP. It was thought that expression of this heavily glycosylated, mucin-type membrane protein was restricted to hematopoietic cells. However, recent advances in the field evidence that CD43 is present in non-lymphoid tissues, particularly tumor cells. Here we reviewed the most important features about this molecule, highlighting the recent advances that have contributed to our understanding of the roles of CD43.
Gene Expression and Protein Structure
CD43 is a type I cell surface glycoprotein abundantly expressed on almost all hematopoietic cells, except for erythrocytes and resting B cells. Although initially considered an immune cell molecule, recent reports...
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