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Androgen Receptor (AR)

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Encyclopedia of Signaling Molecules

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References

  • Attard G, Parker C, Eeles RA, Schroder F, Tomlins SA, Tannock I, et al. Prostate cancer. Lancet. 2016;387:70–82. doi:10.1016/S0140-6736(14)61947-4.

    Article  PubMed  Google Scholar 

  • Baulieu EE, Jung I. A prostatic cytosol receptor. Biochem Biophys Res Commun. 1970;38:599–606.

    Article  PubMed  CAS  Google Scholar 

  • Brinkmann AO. Molecular mechanisms of androgen action – a historical perspective. Methods Mol Biol. 2011;776:3–24. doi:10.1007/978-1-61779-243-4_1.

    Article  PubMed  CAS  Google Scholar 

  • Caffo O, Maines F, Veccia A, Kinspergher S, Galligioni E. Splice variants of androgen receptor and prostate cancer. Oncol Rev. 2016;10:297. doi:10.4081/oncol.2016.297.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Centenera MM, Harris JM, Tilley WD, Butler LM. The contribution of different androgen receptor domains to receptor dimerization and signaling. Mol Endocrinol. 2008;22:2373–82. doi:10.1210/me.2008-0017.

    Article  PubMed  CAS  Google Scholar 

  • Chang CS, Kokontis J, Liao ST. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science. 1988;240:324–6.

    Article  PubMed  CAS  Google Scholar 

  • Dehm S, Tindall DJ. Alternatively spliced androgen receptor variants. Endocr Relat Cancer. 2011. doi:10.1530/ERC-11-0141.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fang S, Anderson KM, Liao S. Receptor proteins for androgens. On the role of specific proteins in selective retention of 17-beta-hydroxy-5-alpha-androstan-3-one by rat ventral prostate in vivo and in vitro. J Biol Chem. 1969;244:6584–95.

    PubMed  CAS  Google Scholar 

  • Foradori CD, Weiser MJ, Handa RJ. Non-genomic actions of androgens. Front Neuroendocrinol. 2008;29:169–81. doi:10.1016/j.yfrne.2007.10.005.

    Article  PubMed  CAS  Google Scholar 

  • Gioeli D, Paschal BM. Post-translational modification of the androgen receptor. Mol Cell Endocrinol. 2011. doi:10.1016/j.mce.2011.07.004.

    Article  PubMed  Google Scholar 

  • Huang P, Chandra V, Rastinejad F. Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics. Annu Rev Physiol. 2010;72:247–72. doi:10.1146/annurev-physiol-021909-135917.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Klokk TI, Kurys P, Elbi C, Nagaich AK, Hendarwanto A, Slagsvold T, et al. Ligand-specific dynamics of the androgen receptor at its response element in living cells. Mol Cell Biol. 2007;27:1823–43. doi:10.1128/MCB.01297-06.

    Article  PubMed  CAS  Google Scholar 

  • Koryakina Y, Ta HQ, Gioeli D. Androgen receptor phosphorylation: biological context and functional consequences. Endocr Relat Cancer. 2014;21:T131–45. doi:10.1530/ERC-13-0472.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kumar R, Atamna H, Zakharov MN, Bhasin S, Khan SH, Jasuja R. Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy. Life Sci. 2011;88:565–71. doi:10.1016/j.lfs.2011.01.021.

    Article  PubMed  CAS  Google Scholar 

  • Lamb DJ, Weigel NL, Marcelli M. Androgen receptors and their biology. Vitam Horm. 2001;62:199–230.

    Article  PubMed  CAS  Google Scholar 

  • Liao RS, Ma S, Miao L, Li R, Yin Y, Raj GV. Androgen receptor-mediated non-genomic regulation of prostate cancer cell proliferation. Transl Androl Urol. 2013;2:187–96. doi:10.3978/j.issn.2223-4683.2013.09.07.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lubahn DB, Joseph DR, Sullivan PM, Willard HF, French FS, Wilson EM. Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science. 1988;240:327–30.

    Article  PubMed  CAS  Google Scholar 

  • Mainwaring WI. A soluble androgen receptor in the cytoplasm of rat prostate. J Endocrinol. 1969;45:531–41.

    Article  PubMed  CAS  Google Scholar 

  • Matsumoto T, Sakari M, Okada M, Yokoyama A, Takahashi S, Kouzmenko A, et al. The androgen receptor in health and disease. Annu Rev Physiol. 2013;75:201–24. doi:10.1146/annurev-physiol-030212-183656.

    Article  PubMed  CAS  Google Scholar 

  • Mills IG. Maintaining and reprogramming genomic androgen receptor activity in prostate cancer. Nat Rev Cancer. 2014;14:187–98. doi:10.1038/nrc3678.

    Article  PubMed  CAS  Google Scholar 

  • Mongan NP, Tadokoro-Cuccaro R, Bunch T, Hughes IA. Androgen insensitivity syndrome. Best Pract Res Clin Endocrinol Metab. 2015;29:569–80. doi:10.1016/j.beem.2015.04.005.

    Article  PubMed  CAS  Google Scholar 

  • Shukla GC, Plaga AR, Shankar E, Gupta S. Androgen receptor-related diseases: what do we know? Andrology. 2016;4:366–81. doi:10.1111/andr.12167.

    Article  PubMed  CAS  Google Scholar 

  • Tilley WD, Marcelli M, Wilson JD, McPhaul MJ. Characterization and expression of a cDNA encoding the human androgen receptor. Proc Natl Acad Sci U S A. 1989;86:327–31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Trapman J, Klaassen P, Kuiper GG, van der Korput JA, Faber PW, van Rooij HC, et al. Cloning, structure and expression of a cDNA encoding the human androgen receptor. Biochem Biophys Res Commun. 1988;153:241–8.

    Article  PubMed  CAS  Google Scholar 

  • van de Wijngaart DJ, Dubbink HJ, van Royen ME, Trapman J, Jenster G. Androgen receptor coregulators: recruitment via the coactivator binding groove. Mol Cell Endocrinol. 2012;352:57–69. doi:10.1016/j.mce.2011.08.007.

    Article  PubMed  CAS  Google Scholar 

  • Wang D, Tindall DJ. Androgen action during prostate carcinogenesis. Methods Mol Biol. 2011;776:25–44. doi:10.1007/978-1-61779-243-4_2.

    Article  PubMed  CAS  Google Scholar 

  • Wilson EM. Analysis of interdomain interactions of the androgen receptor. Methods Mol Biol. 2011;776:113–29. doi:10.1007/978-1-61779-243-4_8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biosciences, University of Oslo, Postboks 1066 Blindern, 0316, Oslo, Norway

    Hatice Zeynep Nenseth, Martina Tesikova & Fahri Saatcioglu

  2. Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway

    Fahri Saatcioglu

Authors
  1. Hatice Zeynep Nenseth
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  2. Martina Tesikova
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  3. Fahri Saatcioglu
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Corresponding author

Correspondence to Fahri Saatcioglu .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Nenseth, H.Z., Tesikova, M., Saatcioglu, F. (2018). Androgen Receptor (AR). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_514

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