PCAF Lysine Acetyltransferase
Historical Background: Identification of PCAF as a Histone Acetyltransferase
Human PCAF was identified in the mid-1990s based on an analogy between yeast and mammalian transcriptional control systems (Yang et al. 1996). In the budding yeast Saccharomyces cerevisiae, starvation for a single amino acid results in derepression of expression of enzymes for different biosynthetic pathways. This phenomenon suggests co-regulation of different pathways and is thus referred to as “general control of amino acid biosynthesis” (Hinnebusch and Fink 1983; Thireos et al. 1984). Genetic screens in the late 1970s and early 1980s uncovered various mutant strains with defects in the gene control response (Wolfner et al. 1975; Hinnebusch and Fink 1983; Penn et al. 1983). Responsible genes of two such mutant strains were named Gcn4 (general control non-derepressible 4, also...
This research was supported by operating grants from Canadian Institutes of Health Research (CIHR) and Canadian Cancer Society (to X.J.Y.).
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