Double-stranded RNA-activated protein kinase; dsRNA-activated inhibitor (DAI); Eukaryotic initiation factor 2α (EIF2α) protein kinase 2 (EIF2AK2); Interferon-inducible EIF2α kinase; Interferon-inducible RNA-dependent protein kinase; P1/eIF2A protein kinase; p68 kinase; Protein kinase interferon-induced double-stranded RNA-activated (PRKR); Protein kinase RNA-activated (PKR)
Protein kinase R (PKR) was identified through its function in regulating host protein synthesis during virus infection (Farrell et al. 1977; Metz and Esteban 1972). This regulation is enacted through phosphorylation of the eukaryotic initiation factor 2α (EIF2α), marking PKR as a member of a small kinase family that constitutes this universal stress response pathway in eukaryotes (Roberts et al. 1976). A number of additional protein substrates for PKR have been identified, although the consequence of this is not well characterized. The transcript’s cDNA was cloned and the...
- Pang Q, Christianson TA, Keeble W, Koretsky T, Bagby GC. The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC. J Biol Chem. 2002;277(51):49638–43.CrossRefPubMedGoogle Scholar
- Tan SL, Tareen SU, Melville MW, Blakely CM, Katze MG. The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation. J Biol Chem. 2002;277(39):36109–17.CrossRefPubMedGoogle Scholar