Notch (Notch1, Notch2, Notch3, Notch4)
Notch mutants in Drosophila melanogaster were originally reported in 1919 (Morgan and Bridges 1919). Notch was named based on the Drosophila melanogaster mutants that exhibited irregular notches of missing tissue at the tips of their wing blades. This phenotype was caused by heterozygous loss-of-function mutations in a gene subsequently named “Notch” that was cloned in 1983 (Artavanis-Tsakonas et al. 1983).
Notch and Notch Signaling
This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs (A084022) and BRL (Basic Research Laboratory) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010–0001200).
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