Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

CD3

  • Anna Morath
  • Sumit Deswal
  • Wolfgang W. A. Schamel
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_507

Synonyms

 CD3γ;  CD3δ;  CD3ε;  T3

Introduction

CD3 is a complex of three type 1 transmembrane (TM) proteins expressed in T cells and most likely also in some neurons: CD3γ, CD3δ, and CD3ε.  CD3ζ (  CD247) is described in a separate chapter due to significant differences compared to CD3γ, CD3δ, and CD3ε. The CD3γ and CD3δ chains are glycoproteins, each of which forms a heterodimer with the nonglycosylated CD3ε chain. These chains associate with TCRαβ and a CD3ζζ dimer to form the αβ T cell antigen receptor (TCR) complex in αβ T cells (Figs. 1 and 2). The CD3 chains and CD3ζζ also associate with pTα and TCRβ to form the pre-TCR and with TCRγδ to form the γδTCR in the case of pre-T cells and γδ T cells, respectively. In murine but not human TCRγδs the CD3εδ heterodimer is replaced by a second CD3εγ heterodimer (Siegers et al. 2007). Each of the CD3 subunits possesses an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic tail, which becomes phosphorylated upon antigen...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Anna Morath
    • 1
    • 2
    • 3
    • 4
  • Sumit Deswal
    • 1
    • 5
    • 6
  • Wolfgang W. A. Schamel
    • 1
    • 2
    • 3
  1. 1.Department of Immunology, Institute for Biology IIIUniversity of FreiburgFreiburgGermany
  2. 2.Centre for Biological Signaling Studies (BIOSS)University of FreiburgFreiburgGermany
  3. 3.Centre of Chronic Immunodeficiency (CCI)University Medical Center Freiburg and University of FreiburgFreiburgGermany
  4. 4.Spemann Graduate School of Biology and MedicineUniversity of FreiburgFreiburgGermany
  5. 5.Max Planck Institute of ImmunobiologyFreiburgGermany
  6. 6.Research Institute of Molecular PathologyViennaAustria