Reference work entry
p130Cas is a major substrate of the Src tyrosine kinase that functions in integrin signaling to promote cell motility, invasion, proliferation, and survival (reviewed by Defillipi et al. 2006; Tikhmyanova et al. 2010). p130Cas was first recognized in the late 1980s by immunoblot detection with an anti-phosphotyrosine antibody in cells transformed by retroviral oncogenes v- crk and v- src. The p130 designation indicates the apparent molecular mass of ∼130 kDa during SDS polyacrylamide gel electrophoresis (PAGE), and Cas is acronymic for “Crk-associated substrate.” Characterization of the direct interactions of p130Cas with the v-Crk and v-Src proteins was significant in the recognition of Src homology 2 (SH2) domains as phosphotyrosine-binding modules in signal transduction. p130Cas was independently identified as a...
- Cunningham-Edmondson AC, Hanks SK. P130Cas substrate domain signaling promotes growth, migration, and invasion of estrogen-receptor-negative breast cancer cells. Breast Cancer Targets Ther. 2009;1:39–52.Google Scholar
- Riggins RB, Thomas KS, Ta HQ, Wen J, Davis RJ, Schuh NR, et al. Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b. Cancer Res. 2006;66:7007–15.CrossRefPubMedGoogle Scholar
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