Skip to main content
SpringerLink
Log in

Sphingosine-1-Phosphate

  • Reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adams DR, Pyne S, Pyne NJ. Sphingosine kinases: emerging structure-function insights. Trends Biochem Sci. 2016;41(5):395–409. doi:10.1016/j.tibs.2016.02.007. Epub 2016/03/30. PubMed PMID: 27021309.

    Article  PubMed  CAS  Google Scholar 

  • Baeyens A, Fang V, Chen C, Schwab SR. Exit strategies: S1P signaling and T cell migration. Trends Immunol. 2015;36(12):778–87. doi:10.1016/j.it.2015.10.005. Epub 2015/11/26. PubMed PMID: 26596799; PubMed Central PMCID: PMC4832571.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Borodzicz S, Czarzasta K, Kuch M, Cudnoch-Jedrzejewska A. Sphingolipids in cardiovascular diseases and metabolic disorders. Lipids Health Dis. 2015;14:55. doi:10.1186/s12944-015-0053-y. Epub 2015/06/17. PubMed PMID: 26076974; PubMed Central PMCID: PMC4470334.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Carroll B, Donaldson JC, Obeid L. Sphingolipids in the DNA damage response. Adv Biol Regul. 2015;58:38–52. doi:10.1016/j.jbior.2014.11.001. Epub 2014/12/02. PubMed PMID: 25434743; PubMed Central PMCID: PMC4425997.

    Article  PubMed  CAS  Google Scholar 

  • Degagne E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, et al. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest. 2014;124(12):5368–84. doi:10.1172/JCI74188. Epub 2014/10/28. PubMed PMID: 25347472; PubMed Central PMCID: PMC4348973.

    Article  PubMed  PubMed Central  Google Scholar 

  • Donati C, Cencetti F, Bruni P. Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology. Front Physiol. 2013;4:338. doi:10.3389/fphys.2013.00338. Epub 2013/12/11. PubMed PMID: 24324439; PubMed Central PMCID: PMC3839259.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gao Y, Gao F, Chen K, Tian ML, Zhao DL. Sphingosine kinase 1 as an anticancer therapeutic target. Drug Des Devel Ther. 2015;9:3239–45. doi:10.2147/DDDT.S83288. Epub 2015/07/08. PubMed PMID: 26150697; PubMed Central PMCID: PMC4484649.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nature reviews. 2008;9(2):139–50. doi:10.1038/nrm2329. Epub 2008/01/25. PubMed PMID: 18216770.

    Article  PubMed  CAS  Google Scholar 

  • Hanson MA, Peach R. Structural biology of the S1P1 receptor. Curr Top Microbiol Immunol. 2014;378:23–53. doi:10.1007/978-3-319-05879-5_2. Epub 2014/04/15. PubMed PMID: 24728592.

    Article  PubMed  CAS  Google Scholar 

  • Kassmer SH, Rodriguez D, Langenbacher AD, Bui C, De Tomaso AW. Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. Nat Commun. 2015;6:8565. doi:10.1038/ncomms9565. Epub 2015/10/13. PubMed PMID: 26456232; PubMed Central PMCID: PMC4606877.

    Article  PubMed  CAS  Google Scholar 

  • Ksiazek M, Chacinska M, Chabowski A, Baranowski M. Sources, metabolism, and regulation of circulating sphingosine-1-phosphate. J Lipid Res. 2015;56(7):1271–81. doi:10.1194/jlr.R059543. Epub 2015/05/28. PubMed PMID: 26014962; PubMed Central PMCID: PMC4479332.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lynch DV, Chen M, Cahoon EB. Lipid signaling in Arabidopsis: no sphingosine? No problem! Trends Plant Sci. 2009;14(9):463–6. doi:10.1016/j.tplants.2009.06.008. Epub 2009/09/01. PubMed PMID: 19716747.

    Article  PubMed  CAS  Google Scholar 

  • Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science (New York, NY). 2002;296(5566):346–9. doi:10.1126/science.1070238. Epub 2002/03/30. PubMed PMID: 11923495.

    Article  CAS  Google Scholar 

  • Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest. 2015;125(4):1379–87. doi:10.1172/JCI76369. Epub 2015/04/02. PubMed PMID: 25831442; PubMed Central PMCID: PMC4409021.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pyne NJ, Pyne S. Sphingosine 1-phosphate and cancer. Nat Rev Cancer. 2010;10(7):489–503. doi:10.1038/nrc2875.

    Article  PubMed  CAS  Google Scholar 

  • Santos WL, Lynch KR. Drugging sphingosine kinases. ACS Chem Biol. 2015;10(1):225–33. doi:10.1021/cb5008426. Epub 2014/11/11. PubMed PMID: 25384187; PubMed Central PMCID: PMC4301069.

    Article  PubMed  CAS  Google Scholar 

  • Schwab S, Pereira J, Matloubian M, Xu Y, Huang Y, Cyster J. Lymphocyte sequestration through S1P lyase inhibition an disruption of S1P gradients. Science. 2005;309:1735–9.

    Article  PubMed  CAS  Google Scholar 

  • Spiegel S, Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev. 2003;4(5):397–407. PubMed PMID: 12728273

    Article  CAS  Google Scholar 

  • Spiegel S, Milstien S. The outs and the ins of sphingosine-1-phosphate in immunity. Nature reviews. 2011;11(6):403–15. doi:10.1038/nri2974. Epub 2011/05/07. PubMed PMID: 21546914; PubMed Central PMCID: PMC3368251.

    Article  PubMed  CAS  Google Scholar 

  • Thuy AV, Reimann CM, Hemdan NY, Graler MH. Sphingosine 1-phosphate in blood: function, metabolism, and fate. Cell Physiol Biochem. 2014;34(1):158–71. doi:10.1159/000362992. Epub 2014/07/01. PubMed PMID: 24977489.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, India

    Ashok Kumar

  2. Center for Cancer Research, UCSF Benioff Children’s Hospital Oakland, Oakland, CA, 94609, USA

    Julie D. Saba

Authors
  1. Ashok Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Julie D. Saba
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ashok Kumar .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Kumar, A., Saba, J.D. (2018). Sphingosine-1-Phosphate. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_452

Download citation

Publish with us

Policies and ethics

Search

Navigation