Adapter proteins participate in intracellular signal transduction processes through physical interaction with catalytically active binding partners resulting in the formation of signaling complexes. Incorporation of adapter proteins into these complexes is mediated by modular binding domains contained in the adapter itself or in the respective binding partner(s). Through incorporation into complexes, adapter proteins modulate the activity of catalytically active proteins, directly or indirectly. In a subtractive cDNA library screen of activated human peripheral blood CD8 T cells, a novel adapter protein was identified that was named T cell specific adapter protein (TSAd) (Spurkland et al. 1998). TSAd is also known as Src-homology 2 (SH2) domain protein 2A (SH2D2A), based upon the presence of an SH2 domain in the center of the linear sequence. Subsequently, murine TSAd was identified as an interacting partner of the Src-family protein...
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