Historical Background
The founding members of the fibroblast growth factor (FGF) family are FGF1 (acidic FGF or aFGF) and FGF2 (basic FGF or bFGF), which were initially purified from bovine brain and pituitary gland as mitogens for fibroblasts. Mouse Fgf3 (int-2) was cloned and characterized as a proto-oncogene that is aberrantly upregulated in mammary tumors due to the proviral integration of mouse mammary tumor virus (MMTV). Human FGF4 (K-FGF) was cloned and characterized as a proto-oncogene following the transfection of genomic DNA from Kaposi sarcoma into mouse NIH 3T3 cells. In addition, 18 FGFs have been cloned and characterized based on their homology to FGF1 ~ FGF4 (Reviewed in Katoh 2002). Because the CCND1 – ORAOV1 – FGF19 – FGF4 – FGF3locus at human...
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet. 2000;26:345–8.
Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, et al. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell. 2012;22:1191–207.
Carpenter TO, Imel EA, Ruppe MD, Weber TJ, Klausner MA, Wooddell MM, et al. Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia. J Clin Invest. 2014;124:1587–97.
Carter EP, Fearon AE, Grose RP. Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction. Trends Cell Biol. 2015;25:221–33.
Dalski A, Atici J, Kreuz FR, Hellenbroich Y, Schwinger E, Zühlke C. Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias. Eur J Hum Genet. 2005;13:118–20.
Degirolamo C, Sabba C, Moschetta A. Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. Nat Rev Drug Discov. 2016;15:51–69.
El Agha E, Kosanovic D, Schermuly RT, Bellusci S. Role of fibroblast growth factors in organ regeneration and repair. Semin Cell Dev Biol. 2016;53:76–84.
Folsom LJ, Imel EA. Hyperphosphatemic familial tumoral calcinosis: genetic models of deficient FGF23 action. Curr Osteoporos Rep. 2015;13:78–87.
Higgins CA, Petukhova L, Harel S, Ho YY, Drill E, Shapiro L, et al. FGF5 is a crucial regulator of hair length in humans. Proc Natl Acad Sci USA. 2014;111:10648–53.
Jamsheer A, Zemojtel T, Kolanczyk M, Stricker S, Hecht J, Krawitz P, et al. Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion. J Med Genet. 2013;50:579–84.
Katoh M. WNT and FGF gene clusters. Int J Oncol. 2002;21:1269–73.
Katoh M. WNT signaling in stem cell biology and regenerative medicine. Curr Drug Targets. 2008;9:565–70.
Katoh M. Therapeutics targeting FGF signaling network in human diseases. Prends Pharmacol Sci. 2016;37:1081–96.
Katoh M, Katoh M. Evolutionary conservation of CCND1 – ORAOV1 – FGF19 – FGF4 locus from zebrafish to human. Int J Mol Med. 2003;12:45–50.
Katoh M, Nakagama H. FGF receptors: cancer biology and therapeutics. Med Res Rev. 2014;34:280–300.
Kirikoshi H, Sagara N, Saitoh T, Sekihara H, Shiokawa K, Katoh M. Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22. Biochem Biophys Res Commun. 2000;274:337–43.
Milunsky JM, Zhao G, Maher TA, Colby R, Everman DB. LADD syndrome is caused by FGF10 mutations. Clin Genet. 2006;69:349–54.
Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, et al. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013;92:725–43.
Ornitz DM, Itoh N. The fibroblast growth factor signaling pathway. Wiley Interdiscip Rev Dev Biol. 2015;4:215–66. .x
Tekin M, Oztürkmen Akay H, Fitoz S, Birnbaum S, Cengiz FB, et al. Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia. Clin Genet. 2008;73:554–65.
Tian H, Zhao Y, Chen N, Wu M, Gong W, Zheng J, et al. High production in E. coli of biologically active recombinant human fibroblast growth factor 20 and its neuroprotective effects. Appl Microbiol Biotechnol. 2016;100:3023–34.
Trarbach EB, Abreu AP, Silveira LF, Garmes HM, Baptista MT, Teles MG, et al. Nonsense mutations in FGF8 gene causing different degrees of human gonadotropin-releasing deficiency. J Clin Endocrinol Metab. 2010;95:3491–6.
Wang G, van der Walt JM, Mayhew G, Li YJ, Züchner S, Scott WK, et al. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of a-synuclein. Am J Hum Genet. 2008;82:283–9.
Zhang J, Li Y. Therapeutic uses of FGFs. Semin Cell Dev Biol. 2016;53:144–54.
Zhao X, Wu Y, Zhao C, Feng M. Association between FGF20 rs12720208 gene polymorphism and Parkinson’s disease: a meta-analysis. Neurol Sci. 2016;37:1119–26.
Zhu R, Zhu Y, Liu X, He Z. Fibroblast growth factor 20 (FGF20) gene polymorphism and risk of Parkinson’s disease: a meta-analysis. Neurol Sci. 2014;35:1889–94.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Katoh, M. (2018). FGF (Fibroblast Growth Factor). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_313
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_313
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences