FGF (Fibroblast Growth Factor)
The founding members of the fibroblast growth factor (FGF) family are FGF1 (acidic FGF or aFGF) and FGF2 (basic FGF or bFGF), which were initially purified from bovine brain and pituitary gland as mitogens for fibroblasts. Mouse Fgf3 (int-2) was cloned and characterized as a proto-oncogene that is aberrantly upregulated in mammary tumors due to the proviral integration of mouse mammary tumor virus (MMTV). Human FGF4 (K-FGF) was cloned and characterized as a proto-oncogene following the transfection of genomic DNA from Kaposi sarcoma into mouse NIH 3T3 cells. In addition, 18 FGFs have been cloned and characterized based on their homology to FGF1 ~ FGF4 (Reviewed in Katoh 2002). Because the CCND1 – ORAOV1 – FGF19 – FGF4...