Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

VDR, the Vitamin D Receptor

  • Marina Rode von Essen
  • Carsten Geisler
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_287

Synonyms

Historical Background

Almost from the time life began, vitamin D has been produced by plants and animals. As the structures of plants and animals became more complex, the sites of vitamin D production, its subsequent metabolism, as well as its sites of action separated. The ability to transport and metabolize vitamin D into more active forms therefore evolved. The metabolic active form 1,25(OH)2D3 of vitamin D exerts its actions through interaction with the vitamin D receptor, VDR (Bikle 2011). Although not as ancient, VDR has been highly conserved between species through evolution (Hochberg and Templeton 2010).VDR is found in almost all cells and tissues of higher-order animals, further emphasizing the importance of the receptor. Evidence for the existence of VDR was first provided in 1969 by Haussler and Norman (Feldman and Pike 2005), and since then a substantial...

This is a preview of subscription content, log in to check access.

References

  1. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 6th ed. Oxford, UK: Elsevier; 2007.Google Scholar
  2. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D, modulator of the immune system. Curr Opin Pharmacol. 2010;10:482–96.CrossRefPubMedGoogle Scholar
  3. Bikle DD. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009;94:26–34.CrossRefPubMedGoogle Scholar
  4. Bikle DD. Vitamin D, an ancient hormone. Exp Dermatol. 2011;20:7–13.CrossRefPubMedGoogle Scholar
  5. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008;29:726–76.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005;289:F8–28.CrossRefPubMedGoogle Scholar
  7. Feldman D, Pike JW, Glorieux FH. Vitamin D. 2nd ed. San Diego: Elsevier; 2005.Google Scholar
  8. Guillot X, Semerano L, Saidenberg-Kermanac’h N, Falgarone G, Boissier MC. Vitamin D and inflammation. Joint Bone Spine. 2010;77:552–7.CrossRefPubMedGoogle Scholar
  9. Hendrickson WK, Flavin R, Kasperzyk JL, Fiorentino M, Fang F, Lis R, Fiore C, Penney KL, Ma J, Kantoff PW, Stampfer MJ, Loda M, Mucci LA, Giovannucci E. Vitamin D receptor protein expression in tumor tissue and prostate cancer progression. J Clin Oncol. 2011;29:2378–85.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Hochberg Z, Templeton AR. Evolutionary perspective in skin color, vitamin D and its receptor. Hormones. 2010;9:307–11.CrossRefPubMedGoogle Scholar
  11. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004;80:1678S–8.CrossRefPubMedGoogle Scholar
  12. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev. 1998;78:1193–231.CrossRefPubMedGoogle Scholar
  13. Lacey DL, Axelrod J, Chappel JC, Kahn AJ, Teitelbaum SL. Vitamin D affects proliferation of a murine T helper cell clone. J Immunol. 1987;138:1680–6.PubMedGoogle Scholar
  14. Lopez N, Sousa B, Martins D, Gomes M, Vieira D, Veronese LA, Milanezi F, Paredes J, Costa JL, Schmitt F. Alterations in vitamin D signaling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions vitamin D pathways unbalanced in breast lesions. BMC Cancer. 2010;10:483–95.CrossRefGoogle Scholar
  15. Luong KVQ, Nguyen LTH. The beneficial role of vitamin D and its analogs in cancer treatment and prevention. Crit Rev Oncol/Hematol. 2010;73:192–201.CrossRefGoogle Scholar
  16. Malloy PJ, Feldman D. Genetic disorders and defects in vitamin D action. Endocrinol Metab Clin N Am. 2010;39:333–46.CrossRefGoogle Scholar
  17. Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 2005;26:662–87.CrossRefPubMedGoogle Scholar
  18. Plum LA, DeLuca HF. Vitamin D, disease and therapeutic opportunities. Nat Rev Drug Discov. 2010;9(12):941–55. doi:10.1038/nrd3318.CrossRefPubMedGoogle Scholar
  19. van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D2:basic concepts. J Steroid Biochem Mol Biol. 2005;97:93–101.CrossRefPubMedGoogle Scholar
  20. von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol. 2010;11:344–9.CrossRefGoogle Scholar
  21. Yee YK, Chintalacharuvu SR, Lu J, Nagpal S. Vitamin D receptor modulators for inflammation and cancer. Mini Rev Med Chem. 2005;5:761–78.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of International Health, Immunology and MicrobiologyUniversity of CopenhagenCopenhagenDenmark
  2. 2.Danish Multiple Sclerosis CenterCopenhagenDenmark