Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

CLK

  • Leonard Rabinow
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_277

Synonyms

Historical Background

CLK1 (cdc2-like) kinase was initially described in mammalian systems (mouse and human cells), and was so-named because of amino-acid sequences similar to cdc2 kinase (now cdk1) in specific kinase catalytic subdomains (Stodjl and Bell 1999 and references therein). CLK1 was also referred to as STY, since it was the first kinase which autophosphorylated with dual-specificity, i.e., on Ser/Thr and Tyr (S/T and Y in the single-letter amino-acid code). Subsequent studies identified four CLK kinases in vertebrate genomes, CLK1-4. The cloning and characterization of the Drosophila orthologue, DOA, enabled the recognition of family members in many additional species, including Arabidopsis thaliana (AFC1-3), Nicotiana tabacum (PK12), Schizosaccharomyces pombe (Lkh1), and Saccharomyces cerevisiae (KNS1) (Yun et al. 1994; Savaldi-Goldstein et al. 2003; Kang et al. 2010and references therein). These were collectively...

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Notes

Acknowledgments

I apologize to the colleagues working on the LAMMER protein kinases whose excellent work could not be completely described or cited due to severe limitations on space and the number of references allowed. Wherever possible I have cited the most recent reference from each group to allow readers to identify prior citations of interest. Work in the laboratory of LR is supported by the University of Paris Sud and the CNRS.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Université Paris Sud, CNRS UMR 8195OrsayFrance