G-protein-coupled receptors constitute the largest and most diverse family of integral membrane proteins and are involved in a wide variety of physiological functions. Some of these functions include mediating responses to hormones, neurotransmitters, odorants and light, and regulation of the immune system and inflammation (Yousefi et al. 2001; Lattin et al. 2008; Weis and Kobilka 2008; Gloriam et al. 2009). GPR84 belongs to the rhodopsin subfamily of G-protein-coupled receptors and was first discovered during a comprehensive search of available expressed sequence tags (EST; Wittenberger et al. 2001). Since its discovery, GPR84 has been found in many human tissues, in mouse spleen, liver, spinal cord and sciatic nerve, in embryonic Xenopus laevistissues, and zebrafish intestine, heart, and liver. This receptor was considered an orphan receptor until late 2006, when it was discovered that GPR84 functions as a...
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