The human BTG/Tob proteins form a small family of six proteins, which share a conserved N-terminal domain and antiproliferative activity (Matsuda et al. 2001; Tirone 2001; Winkler 2010). BTG2 was discovered first by two laboratories: as the immediate/early response gene PC3 in rat PC12 cells stimulated with nerve growth factor (NGF) and as TIS21 in mouse 3T3 fibroblasts in response to treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). The discovery of BTG1 (B-cell translocation gene 1) as a gene involved in a chromosomal translocation associated with chronic lymphocytic leukemia suggested the presence of a new family of antiproliferative genes. These findings were extended by the discovery of TOB1, which was found as an interacting protein of the ErbB2 tyrosine-kinase receptor (HER2). The remaining three members BTG3 (ANA),...
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