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RGS13

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References

  • Bansal G, Druey KM, Xie Z. R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacol Ther. 2007;116:473–95.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bansal G, Xie Z, Rao S, Nocka KH, Druey KM. Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13. Nat Immunol. 2008a;9:73–80.

    Article  PubMed  CAS  Google Scholar 

  • Bansal G, DiVietro JA, Kuehn HS, Rao S, Nocka KH, Gilfillan AM, Druey KM. RGS13 controls G protein-coupled receptor-evoked responses of human mast cells. J Immunol. 2008b;181:7882–90.

    Article  PubMed  CAS  Google Scholar 

  • Druey KM, Blumer KJ, Kang VH, Kehrl JH. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature. 1996;379:742–6.

    Article  PubMed  CAS  Google Scholar 

  • Fujita N, Jaye DL, Geigerman C, Akyildiz A, Mooney MR, Boss JM, Wade PA. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell. 2004;119:75–86.

    Article  PubMed  CAS  Google Scholar 

  • Gilfillan AM, Tkaczyk C. Integrated signalling pathways for mast-cell activation. Nat Rev Immunol. 2006;6:218–30.

    Article  PubMed  CAS  Google Scholar 

  • Grafstein-Dunn E, Young KH, Cockett MI, Khawaja XZ. Regional distribution of regulators of G-protein signaling (RGS) 1, 2, 13, 14, 16, and GAIP messenger ribonucleic acids by in situ hybridization in rat brain. Brain Res Mol Brain Res. 2001;88:113–23.

    Article  PubMed  CAS  Google Scholar 

  • Han JI, Huang NN, Kim DU, Kehrl JH. RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. J Leukoc Biol. 2006;79:1357–68.

    Article  PubMed  CAS  Google Scholar 

  • Hsu HC, Yang P, Wang J, Wu Q, Myers R, Chen J, Yi J, Guentert T, Tousson A, Stanus AL, Le TV, Lorenz RG, Xu H, Kolls JK, Carter RH, Chaplin DD, Williams RW, Mountz JD. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol. 2008;9:166–75.

    Article  PubMed  CAS  Google Scholar 

  • Hunt TW, Fields TA, Casey PJ, Peralta EG. RGS10 is a selective activator of G alpha i GTPase activity. Nature. 1996;383:175–7.

    Article  PubMed  CAS  Google Scholar 

  • Hwang IY, Hwang KS, Park C, Harrison KA, Kehrl JH. RGS13 constrains early B cell responses and limits germinal center sizes. PLoS One. 2013;8:e60139.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Islam TC, Asplund AC, Lindvall JM, Nygren L, Liden J, Kimby E, Christensson B, Smith CI, Sander B. High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma. Leukemia. 2003;17:1880–90.

    Article  PubMed  CAS  Google Scholar 

  • Iwaki S, Lu Y, Xie Z, Druey KM. p53 negatively regulates RGS13 protein expression in immune cells. J Biol Chem. 2011; epublished ahead of print.

    Google Scholar 

  • Johnson EN, Druey KM. Functional characterization of the G protein regulator RGS13. J Biol Chem. 2002;277:16768–74.

    Article  PubMed  CAS  Google Scholar 

  • Larminie C, Murdock P, Walhin JP, Duckworth M, Blumer KJ, Scheideler MA, Garnier M. Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. Brain Res Mol Brain Res. 2004;122:24–34.

    Article  PubMed  CAS  Google Scholar 

  • Neitzel KL, Hepler JR. Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling. Semin Cell Dev Biol. 2006;17:383–9.

    Article  PubMed  CAS  Google Scholar 

  • Patel TB. Single transmembrane spanning heterotrimeric g protein-coupled receptors and their signaling cascades. Pharmacol Rev. 2004;56:371–85.

    Article  PubMed  CAS  Google Scholar 

  • Pise-Masison CA, Radonovich M, Dohoney K, Morris JC, O’Mahony D, Lee MJ, Trepel J, Waldmann TA, Janik JE, Brady JN. Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability. Blood. 2009;113:4016–26.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sethakorn N, Dulin N. RGS expression in cancer: oncomining the cancer microarray data. J Recept Signal Transduct Res. 2013;33:166–71.

    Article  PubMed  CAS  Google Scholar 

  • Shi GX, Harrison K, Wilson GL, Moratz C, Kehrl JH. RGS13 regulates germinal center B lymphocytes responsiveness to CXC chemokine ligand (CXCL)12 and CXCL13. J Immunol. 2002;169:2507–15.

    Article  PubMed  CAS  Google Scholar 

  • Thompson MD, Cole DE, Jose PA. Pharmacogenomics of G protein-coupled receptor signaling: insights from health and disease. Methods Mol Biol. 2008;448:77–107.

    Article  PubMed  CAS  Google Scholar 

  • Wang JH, New JS, Xie S, Yang PA, Wu Q, Li J, Luo B, Ding Y, Druey KM, Hsu HC, Mountz J. Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice. Arthritis Rheum. 2013;65:2703–12.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Watson N, Linder ME, Druey KM, Kehrl JH, Blumer KJ. RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits. Nature. 1996;383:172–5.

    Article  PubMed  CAS  Google Scholar 

  • Xie Z, Geiger TR, Johnson EN, Nyborg JK, Druey KM. RGS13 acts as a nuclear repressor of CREB. Mol Cell. 2008;31:660–70.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Xie Z, Yang Z, Druey KM. Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation. J Mol Cell Biol. 2010;2:357–65.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgments

This study was supported by the Intramural Research Program of the NIH, NIAID.

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Correspondence to Zhihui Xie .

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Xie, Z., Druey, K.M. (2018). RGS13. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_261

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