Regulator of G-protein signaling (RGS) is a protein superfamily discovered in the mid-1990s (Druey et al. 1996; Watson et al. 1996; Hunt et al. 1996). Since that time, more than 30 members in the family have been identified. The major physiological function of RGS molecules is to negatively modulate G-protein-coupled receptor (GPCR)-mediated signaling and biology (Bansal et al. 2007; Neitzel and Hepler 2006; Thompson et al. 2008). RGS13 was first identified in 1996 and is one of the smallest molecules in the family (Druey et al. 1996). Full-length human RGS13 cDNA was cloned and deposited into gene bank in 1997 by Chatterjee and Fisher. In 2002, the first functional studies of human RGS13 were reported. RGS13 was shown to inhibit muscarinic M1- and M2 receptor-induced MAP kinase activation (Johnson and Druey 2002). Concurrently, a separate study characterized mouse RGS13, which was cloned from B cells. RGS13...
This study was supported by the Intramural Research Program of the NIH, NIAID.
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