Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Masaaki Kobayashi
  • Ken TakamatsuEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_251



Historical Background

Hippocalcin was originally cloned from a rat brain cDNA library based on the partial amino acid sequences from a calcium-binding protein with a molecular mass of 23,000 Da (P23k), which was purified during a survey of recoverin-like immunoreactivity in the brain (Kobayashi et al. 1992). During the 1990s, a number of calcium-binding proteins structurally related to hippocalcin were identified in the nervous system and named NCS (neuronal calcium sensor) proteins. There are 14 protein-coding genes in the NCS family in the human genome (Burgoyne 2007). Hippocalcin is a highly conserved protein and has an identical amino acid sequence in rat, mouse, bovine, and human (Kobayashi and Takamatsu 2009).

Protein Chemical Characteristics

Hippocalcin, a 23 kDa protein of 193 amino acid residues containing 10 α-helices and 2 antiparallel β-sheets, has three functional EF-hand calcium-binding domains and an N-terminal glycine residue covalently linked to myristic...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of PhysiologyToho University School of MedicineTokyoJapan