Historical Background
Around the beginnings of the 1990s several cytogenetic studies reported the occurrence of t(11;18)(q21;q21) chromosomal translocations in several cases of low-grade Mucosa-Associated Lymphoid Tissue (MALT) lymphoma. Later, Akagi and colleagues identified a novel gene on chromosome 18 to be involved in the t(11;18)(q21;q21) translocation which they named MALT1 as a candidate gene involved in the pathogenesis of MALT lymphoma (Akagi et al. 1999). Already a few months earlier, Dierlamm and colleagues also reported MALT1 (which they named MLT) as part of the t(11;18)(q21;q21) translocation as well its translocation partner on chromosome 11, the API2 gene, resulting in the expression of a 5′-API2-MALT1-3′ fusion transcript (Dierlamm et al. 1999). While the function of the MALT1 gene product was completely unclear at that time, the API2gene had already been known to encode for a...
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We thank Frank Oliver Gorka for thoughtfully reading and discussing the manuscript.
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Gewies, A., Ruland, J. (2018). MALT1(Mucosa-Associated Lymphoid Tissue Translocation Gene 1). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_234
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DOI: https://doi.org/10.1007/978-3-319-67199-4_234
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