Nucleotide Receptor P2Y
Signaling by extracellular ATP was first reported in 1929 (Drury and Szent-Györgyi 1929). Subdivision of purinergic receptors between P1 (adenosine) and P2 (ATP, ADP) was proposed in 1978 (Burnstock 1978), and further subdivision of P2 receptors between P2Y and P2X was made in 1985 (Burnstock and Kennedy 1985). The P2Y1 and P2Y2 receptors were the first P2Y receptors to be cloned in 1993 (Webb et al. 1993; Lustig et al. 1993).
Release of Nucleotides in the Extracellular Fluids
Although nucleotides, such as ATP and UTP, are mainly intracellular, they are released in the extracellular fluids by various mechanisms. One of them is cell damage: both necrotic and apoptotic cells release ATP and other nucleotides that thus constitute “danger signals” or DAMP (damage-associated molecular pattern) (Elliott et al. 2009). But they can also be released without cell lysis by specific mechanisms: exocytosis of secretory...
- Abbracchio MP, Burnstock G, Boeynaems J-M, Barnard EA, Boyer JL, Kennedy C, et al. International Union of Pharmacology. Update and subclassification of the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006;58:281–341.PubMedPubMedCentralCrossRefGoogle Scholar
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