Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Dbf4

  • Hisao MasaiEmail author
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-319-67199-4_186
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Synonyms

 ASK (activator of S phase kinase)/huDbf4 (human);  Chiffon (Drosophila);  Dbf4 (dumbbell former 4)/DNA52 (Saccharomyces cerevisiae);  Dbf4l1;  Dfp1/Him1/Rad35 (Schizosaccharomyces pombe);  Drf1/ASKL1 (a second activator of Cdc7 in human and Xenopus);  nimO (Aspergillus);  Spo6 (a second Dbf4 homologue in S. pombe)

Historical Background

dbf4 (dumbbell former 4) mutation was originally identified in the screening for budding yeast temperature-sensitive mutants which arrest with dumbbell-shaped phenotype at the nonpermissive temperature (Johnston and Thomas 1982). The terminal phenotypes of dbf4(ts) strain at a non-permissive temperature were very similar to those of cdc7 (ts), encoding a serine-threonine kinase known to be essential for initiation of DNA replication. Later, dbf4 was rediscovered as a multi-copy suppressor of cdc7(ts), suggesting physical and functional interactions between Cdc7 and Dbf4 (Kitada et al. 1992). Following this finding, Dbf4 was shown to bind to...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Genome Dynamics Project, Department of Genome MedicineTokyo Metropolitan Institute of Medical ScienceTokyoJapan