P-Rex1 ( BC067047; G630042G04; KIAA1415; mKIAA1415; Phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger; PREX1; P-Rex1), P-Rex2 ( DEP domain containing 2; DEP.2; Depdc2; phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 2; PREX2; P-Rex2; PtdIns(3,4,5)-dependent Rac exchanger 2)
A phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger (P-Rex) is an intracellular signaling molecule that regulates leukocyte function and neuronal development by activating a small guanine nucleotide-binding protein, Rac. The Homo sapiens genome encodes two P-Rex genes, P-Rex1 and P-Rex2. In 2002, Welch et al. purified a PIP3-dependent Rac activator from pig neutrophil lysates, identified a 196 kDa Dbl-like GEF (guanine nucleotide exchange factor) protein for Rac, and designated it as P-Rex1 (Welch et al. 2002). They characterized its synergistic activation by Gβγ subunits of heterotrimeric G proteins and PIP3, and its...