Skip to main content

NEKs, NIMA-Related Kinases

  • Reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bahmanyar S, Kaplan DD, Deluca JG, Giddings Jr TH, O’Toole ET, Winey M, Salmon ED, Casey PJ, Nelson WJ, Barth AI. Beta-catenin is a Nek2 substrate involved in centrosome separation. Genes Dev. 2008;22:91–105.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem. 2003;278:34897–909.

    Article  CAS  PubMed  Google Scholar 

  • Bertran MT, Sdelci S, Regué L, Avruch J, Caelles C, Roig J. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J. 2011;30:2634–47.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bradley BA, Quarmby LM. A NIMA-related kinase, Cnk2p, regulates both flagellar length and cell size in Chlamydomonas. J Cell Sci. 2005;118:3317–26.

    Article  CAS  PubMed  Google Scholar 

  • Capra M, Nuciforo PG, Confalonieri S, Quarto M, Bianchi M, Nebuloni M, Boldorini R, Pallotti F, Viale G, Gishizky ML, Draetta GF, Di Fiore PP. Frequent alterations in the expression of serine/threonine kinases in human cancers. Cancer Res. 2006;66:8147–54.

    Article  CAS  PubMed  Google Scholar 

  • Chang J, Baloh RH, Milbrandt J. The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. J Cell Sci. 2009;122:2274–82.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen Y, Chen CF, Chiang HC, Pena M, Polci R, Wei RL, Edwards RA, Hansel DE, Chen PL, Riley DJ. Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability. Mol Cancer. 2011;10:5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Doles J, Hemann MT. Nek4 status differentially alters sensitivity to distinct microtubule poisons. Cancer Res. 2010;70:1033–41.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Eto M, Elliott E, Prickett TD, Brautigan DL. Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. J Biol Chem. 2002;277:44013–20.

    Article  CAS  PubMed  Google Scholar 

  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O’Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II B, Kuehl K, Hogue K, Colwill K, Gladwish B, Muskat R, Kinach SL, Adams MF, Moran GB, Morin TT, Figeys D. Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Faragher AJ, Fry AM. Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles. Mol Biol Cell. 2003;14:2876–89.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fletcher L, Cerniglia GJ, Yen TJ, Muschel RJ. Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B. Biochim Biophys Acta. 2005;1744:89–92.

    Article  CAS  PubMed  Google Scholar 

  • Fry AM. The Nek2 protein kinase: a novel regulator of centrosome structure. Oncogene. 2002;21:6184–94.

    Article  CAS  PubMed  Google Scholar 

  • Fry AM, Schultz SJ, Bartek J, Nigg EA. Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans. J Biol Chem. 1995;270:12899–905.

    Article  CAS  PubMed  Google Scholar 

  • Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA. C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J Cell Biol. 1998a;141:1563–74.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fry AM, Meraldi P, Nigg EA. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. EMBO J. 1998b;17:470–81.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Grallert A, Hagan IM. Schizosaccharomyces pombe NIMA-related kinase, Fin1, regulates spindle formation and an affinity of Polo for the SPB. EMBO J. 2002;21:3096–107.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Grallert A, Krapp A, Bagley S, Simanis V, Hagan IM. Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity. Genes Dev. 2004;18:1007–21.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hames RS, Crookes RE, Straatman KR, Merdes A, Hayes MJ, Faragher AJ, Fry AM. Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation. Mol Biol Cell. 2005;16:1711–24.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hayes MJ, Kimata Y, Wattam SL, Lindon C, Mao G, Yamano H, Fry AM. Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C. Nat Cell Biol. 2006;8:607–14.

    Article  CAS  PubMed  Google Scholar 

  • Hayward DG, Fry AM. Nek2 kinase in chromosome instability and cancer. Cancer Lett. 2006;237:155–66.

    Article  CAS  PubMed  Google Scholar 

  • Hayward DG, Newbatt Y, Pickard L, Byrne E, Mao G, Burns S, Sahota NK, Workman P, Collins I, Aherne W, Fry AM. Identification by high-throughput screening of viridin analogs as biochemical and cell-based inhibitors of the cell cycle-regulated Nek2 kinase. J Biomol Screen. 2010;15:918–27.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Helps NR, Luo X, Barker HM, Cohen PT. NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. Biochem J. 2000;349:509–18.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD. Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. J Biol Chem. 2002;277:16229–40.

    Article  CAS  PubMed  Google Scholar 

  • Jeon YJ, Lee KY, Cho YY, Pugliese A, Kim HG, Jeong CH, Bode AM, Dong Z. Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells. J Biol Chem. 2010;285:28126–33.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jin G, Aulabaugh A, Pocas J, Liu H, Kriz R, Sampath D. Development and comparison of nonradioactive in vitro kinase assays for NIMA-related kinase 2. Anal Biochem. 2006;358:59–69.

    Article  CAS  PubMed  Google Scholar 

  • Kim S, Lee K, Rhee K. NEK7 is a centrosomal kinase critical for microtubule nucleation. Biochem Biophys Res Commun. 2007;360:56–62.

    Article  CAS  PubMed  Google Scholar 

  • Kokuryo T, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M. Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma. Cancer Res. 2007;67:9637–42.

    Article  CAS  PubMed  Google Scholar 

  • Laurell E, Beck K, Krupina K, Theerthagiri G, Bodenmiller B, Horvath P, Aebersold R, Antonin W, Kutay U. Phosphorylation of Nup98 by multiple kinases Is crucial for NPC disassembly during mitotic entry. Cell. 2011;144:539–50.

    Article  CAS  PubMed  Google Scholar 

  • Letwin K, Mizzen L, Motro B, Ben-David Y, Bernstein A, Pawson T. A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J. 1992;11:3521–31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Liu S, Lu W, Obara T, Kuida S, Lehoczky J, Dewar K, Drummond IA, Beier DR. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development. 2002;129:5839–46.

    Article  CAS  PubMed  Google Scholar 

  • Lu KP, Hunter T. Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell. 1995;81:413–24.

    Article  CAS  PubMed  Google Scholar 

  • Mahjoub MR, Montpetit B, Zhao L, Finst RJ, Goh B, Kim AC, Quarmby LM. The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation. J Cell Sci. 2002;115:1759–68.

    CAS  PubMed  Google Scholar 

  • Mahjoub MR, Trapp ML, Quarmby LM. NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. J Am Soc Nephrol. 2005;16:3485–9.

    Article  CAS  PubMed  Google Scholar 

  • Mardin BR, Lange C, Baxter JE, Hardy T, Scholz SR, Fry AM, Schiebel E. Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat Cell Biol. 2010;12:1166–76.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Melixetian M, Klein DK, Sørensen CS, Helin K. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol. 2009;11:1247–53.

    Article  CAS  PubMed  Google Scholar 

  • Miller SL, DeMaria JE, Freier DO, Riegel AM, Clevenger CV. Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. Mol Endocrinol. 2005;19:939–49.

    Article  CAS  PubMed  Google Scholar 

  • Miller SL, Antico G, Raghunath PN, Tomaszewski JE, Clevenger CV. Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells. Oncogene. 2007;26:4668–78.

    Article  CAS  PubMed  Google Scholar 

  • Moniz LS, Stambolic V. Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation. Mol Cell Biol. 2011;31:30–42.

    Article  CAS  PubMed  Google Scholar 

  • Morris N. Mitotic mutants of Aspergillus nidulans. Genet Res. 1975;26:237–54.

    Article  CAS  PubMed  Google Scholar 

  • Nassirpour R, Shao L, Flanagan P, Abrams T, Jallal B, Smeal T, Yin MJ. Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target. Mol Cancer Res. 2010;8:717–28.

    Article  CAS  PubMed  Google Scholar 

  • Noguchi K, Fukazawa H, Murakami Y, Uehara Y. Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses. J Biol Chem. 2002;277:39655–65.

    Article  CAS  PubMed  Google Scholar 

  • Noguchi K, Fukazawa H, Murakami Y, Uehara Y. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells. J Biol Chem. 2004;279:32716–27.

    Article  CAS  PubMed  Google Scholar 

  • O’Connell MJ, Norbury C, Nurse P. Premature chromatin condensation upon accumulation of NIMA. EMBO J. 1994;13:4926–37.

    Article  PubMed  PubMed Central  Google Scholar 

  • O’Connell MJ, Krien MJ, Hunter T. Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol. 2003;13:221–8.

    Article  CAS  PubMed  Google Scholar 

  • O’Regan L, Blot J, Fry AM. Mitotic regulation by NIMA-related kinases. Cell Div. 2007;2:25.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • O’Regan L, Fry AM. The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. Mol Cell Biol. 2009;29:3975–90.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Oakley BR, Morris NR. A mutation in Aspergillus nidulans that blocks the transition from interphase to prophase. J Cell Biol. 1983;96:1155–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Osmani SA, Pu RT, Morris NR. Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase. Cell. 1988;53:237–44.

    Article  CAS  PubMed  Google Scholar 

  • Osmani AH, O’Donnell K, Pu RT, Osmani SA. Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint. EMBO J. 1991;10:2669–79.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Otto EA, Trapp ML, Schultheiss UT, Helou J, Quarmby LM, Hildebrandt F. NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis. J Am Soc Nephrol. 2008;19:587–92.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Parker JD, Bradley BA, Mooers AO, Quarmby LM. Phylogenetic analysis of the Neks reveals early diversification of ciliary-cell cycle kinases. PLoS One. 2007;2:e1076.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Polci R, Peng A, Chen PL, Riley DJ, Chen Y. NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res. 2004;64:8800–3.

    Article  CAS  PubMed  Google Scholar 

  • Pugacheva EN, Golemis EA. The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat Cell Biol. 2005;7:937–46.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Qiu XL, Li G, Wu G, Zhu J, Zhou L, Chen PL, Chamberlin AR, Lee WH. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J Med Chem. 2009;52:1757–67.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Quarmby LM, Mahjoub MR. Caught Nek-ing: cilia and centrioles. J Cell Sci. 2005;118:5161–9.

    Article  CAS  PubMed  Google Scholar 

  • Rapley J, Nicolas M, Groen A, Regue L, Bertran MT, Caelles C, Avruch J, Roig J. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J Cell Sci. 2008;121:3912–21.

    Article  PubMed  CAS  Google Scholar 

  • Rellos P, Ivins FJ, Baxter JE, Pike A, Nott TJ, Parkinson DM, Das S, Howell S, Fedorov O, Shen QY, Fry AM, Knapp S, Smerdon SJ. Structure and regulation of the human Nek2 centrosomal kinase. J Biol Chem. 2007;282:6833–42.

    Article  CAS  PubMed  Google Scholar 

  • Richards MW, O’Regan L, Mas-Droux C, Blot JM, Cheung J, Hoelder S, Fry AM, Bayliss R. An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. Mol Cell. 2009;36:560–70.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Roig J, Mikhailov A, Belham C, Avruch J. Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev. 2002;16:1640–58.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Roig J, Groen A, Caldwell J, Avruch J. Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly. Mol Biol Cell. 2005;16:4827–40.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Salem H, Rachmin I, Yissachar N, Cohen S, Amiel A, Haffner R, Lavi L, Motro B. Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy. Oncogene. 2010;29:4046–57.

    Article  CAS  PubMed  Google Scholar 

  • Schultz SJ, Fry AM, Sutterlin C, Ried T, Nigg EA. Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. Cell Growth Differ. 1994;5:625–35.

    CAS  PubMed  Google Scholar 

  • Shalom O, Shalva N, Altschuler Y, Motro B. The mammalian Nek1 kinase is involved in primary cilium formation. FEBS Lett. 2008;582:1465–70.

    Article  CAS  PubMed  Google Scholar 

  • Shiba D, Manning DK, Koga H, Beier DR, Yokoyama T. Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia. Cytoskeleton (Hoboken). 2010;67:112–9.

    CAS  PubMed  Google Scholar 

  • Sohara E, Luo Y, Zhang J, Manning DK, Beier DR, Zhou J. Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol. 2008;19:469–76.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sørensen CS, Melixetian M, Klein DK, Helin K. NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling. Cell Cycle. 2010;9:450–5.

    Article  PubMed  Google Scholar 

  • Surpili MJ, Delben TM, Kobarg J. Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. Biochemistry. 2003;42:15369–76.

    Article  CAS  PubMed  Google Scholar 

  • Suzuki K, Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M. Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin. Cancer Sci. 2010;101:1163–9.

    Article  CAS  PubMed  Google Scholar 

  • Tan BC, Lee SC. Nek9, a novel FACT-associated protein, modulates interphase progression. J Biol Chem. 2004;279:9321–30.

    Article  CAS  PubMed  Google Scholar 

  • Tanaka K, Nigg EA. Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators. J Biol Chem. 1999;274:13491–7.

    Article  CAS  PubMed  Google Scholar 

  • Trapp ML, Galtseva A, Manning DK, Beier DR, Rosenblum ND, Quarmby LM. Defects in ciliary localization of Nek8 is associated with cystogenesis. Pediatr Nephrol. 2008;23:377–87.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tsunoda N, Kokuryo T, Oda K, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M. Nek2 as a novel molecular target for the treatment of breast carcinoma. Cancer Sci. 2009;100:111–6.

    Article  CAS  PubMed  Google Scholar 

  • Upadhya P, Birkenmeier EH, Birkenmeier CS, Barker JE. Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice. Proc Natl Acad Sci USA. 2000;97:217–21.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Uto K, Sagata N. Nek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos. EMBO J. 2000;19:1816–26.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vaz Meirelles G, Ferreira Lanza DC, da Silva JC, Santana Bernachi J, Paes Leme AF, Kobarg J. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J Proteome Res. 2010;9:6298–316.

    Article  CAS  PubMed  Google Scholar 

  • Vogler C, Homan S, Pung A, Thorpe C, Barker J, Birkenmeier EH, Upadhya P. Clinical and pathologic findings in two new allelic murine models of polycystic kidney disease. J Am Soc Nephrol. 1999;10:2534–9.

    CAS  PubMed  Google Scholar 

  • Whelligan DK, Solanki S, Taylor D, Thomson DW, Cheung K-M, Boxall K, Mas-Droux C, Barillari C, Burns S, Grummitt CG, Collins I, van Montfort RLM, Aherne GW, Bayliss R, Hoelder S. Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem. 2010;53(21):7682–98.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • White MC, Quarmby LM. The NIMA-family kinase, Nek1 affects the stability of centrosomes and ciliogenesis. BMC Cell Biol. 2008;9:29.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wloga D, Camba A, Rogowski K, Manning G, Jerka-Dziadosz M, Gaertig J. Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms. Mol Biol Cell. 2006;17:2799–810.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wu W, Baxter JE, Wattam SL, Hayward DG, Fardilha M, Knebel A, Ford EM, da Cruz e Silva EF, Fry AM. Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase. J Biol Chem. 2007;282:26431–40.

    Article  CAS  PubMed  Google Scholar 

  • Wu G, Qiu XL, Zhou L, Zhu J, Chamberlin R, Lau J, Chen PL, Lee WH. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008;68:8393–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yin MJ, Shao L, Voehringer D, Smeal T, Jallal B. The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. J Biol Chem. 2003;278:52454–60.

    Article  CAS  PubMed  Google Scholar 

  • Yissachar N, Salem H, Tennenbaum T, Motro B. Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. FEBS Lett. 2006;580:6489–95.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Navdeep Sahota .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Sahota, N. et al. (2018). NEKs, NIMA-Related Kinases. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_17

Download citation

Publish with us

Policies and ethics