Skip to main content

AIFM1

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Armand AS, Laziz I, Djeghloul D, Lecolle S, Bertrand AT, Biondi O, et al. Apoptosis-inducing factor regulates skeletal muscle progenitor cell number and muscle phenotype. PLoS One. 2011;6:e27283. doi:10.1371/journal.pone.0027283.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Artus C, Boujrad H, Bouharrour A, Brunelle MN, Hoos S, Yuste VJ, et al. AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J. 2010;29:1585–99. doi:10.1038/emboj.2010.43.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Banerjee H, Das A, Srivastava S, Mattoo HR, Thyagarajan K, Khalsa JK, et al. A role for apoptosis-inducing factor in T cell development. J Exp Med. 2012;209:1641–53. doi:10.1084/jem.20110306.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Berger I, Ben-Neriah Z, Dor-Wolman T, Shaag A, Saada A, Zenvirt S, et al. Early prenatal ventriculomegaly due to an AIFM1 mutation identified by linkage analysis and whole exome sequencing. Mol Genet Metab. 2011;104:517–20. doi:10.1016/j.ymgme.2011.09.020.

    Article  PubMed  CAS  Google Scholar 

  • Cheung EC, Joza N, Steenaart NA, McClellan KA, Neuspiel M, McNamara S, et al. Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J. 2006;25:4061–73. doi:10.1038/sj.emboj.7601276.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Elguindy MM, Nakamaru-Ogiso E. Apoptosis-inducing factor (AIF) and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (NDH-2). J Biol Chem. 2015;290:20815–26. doi:10.1074/jbc.M115.641498.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Farrand L, Kim JY, Byun S, Im-aram A, Lee J, Suh JY, et al. The diarylheptanoid hirsutenone sensitizes chemoresistant ovarian cancer cells to cisplatin via modulation of apoptosis-inducing factor and X-linked inhibitor of apoptosis. J Biol Chem. 2014;289:1723–31. doi:10.1074/jbc.M113.513879.

    Article  PubMed  CAS  Google Scholar 

  • Ghezzi D, Sevrioukova IF, Invernizzi F, Lamperti C, Mora M, D’Adamo P, et al. Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor. Am J Hum Genet. 2010;86:639–49.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gong M, Hay S, Marshall KR, Munro AW, Scrutton NS. DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis. J Biol Chem. 2007;282:30331–40. doi:10.1074/jbc.M703713200.

    Article  PubMed  CAS  Google Scholar 

  • Hangen E, Blomgren K, Benit P, Kroemer G, Modjtahedi N. Life with or without AIF. Trends Biochem Sci. 2010a;35:278–87. doi:10.1016/j.tibs.2009.12.008.

    Article  PubMed  CAS  Google Scholar 

  • Hangen E, De Zio D, Bordi M, Zhu C, Dessen P, Caffin F, et al. A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2. Cell Death Differ. 2010b;17:1155–66. doi:10.1038/cdd.2009.211.

    Article  PubMed  CAS  Google Scholar 

  • Hangen E, Feraud O, Lachkar S, Mou H, Doti N, Fimia GM, et al. Interaction between AIF and CHCHD4 regulates respiratory chain biogenesis. Mol Cell. 2015;58:1001–14. doi:10.1016/j.molcel.2015.04.020.

    Article  PubMed  CAS  Google Scholar 

  • Herrmann JM, Riemer J. The intermembrane space of mitochondria. Antioxid Redox Signal. 2010;13:1341–58. doi:10.1089/ars.2009.3063.

    Article  PubMed  CAS  Google Scholar 

  • Ishimura R, Martin GR, Ackerman SL. Loss of apoptosis-inducing factor results in cell-type-specific neurogenesis defects. J Neurosci. 2008;28:4938–48. doi:10.1523/JNEUROSCI.0229-08.2008.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Joza N, Oudit GY, Brown D, Benit P, Kassiri Z, Vahsen N, et al. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol. 2005;25:10261–72. doi:10.1128/MCB.25.23.10261-10272.2005.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lewis EM, Wilkinson AS, Davis NY, Horita DA, Wilkinson JC. Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation. Biochemistry. 2011;50:11084–96. doi:10.1021/bi201483g.

    Article  PubMed  CAS  Google Scholar 

  • Lewis EM, Wilkinson AS, Jackson JS, Mehra R, Varambally S, Chinnaiyan AM, et al. The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells. J Biol Chem. 2012;287:43862–75. doi:10.1074/jbc.M112.407650.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Marshall KR, Gong M, Wodke L, Lamb JH, Jones DJ, Farmer PB, et al. The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity. J Biol Chem. 2005;280:30735–40. doi:10.1074/jbc.M414018200.

    Article  PubMed  CAS  Google Scholar 

  • Meyer K, Buettner S, Ghezzi D, Zeviani M, Bano D, Nicotera P. Loss of apoptosis-inducing factor critically affects MIA40 function. Cell Death Dis. 2015;6:e1814. doi:10.1038/cddis.2015.170.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Milasta S, Dillon CP, Sturm OE, Verbist KC, Brewer TL, Quarato G, et al. Apoptosis-inducing-factor-dependent mitochondrial function is required for T cell but not B cell function. Immunity. 2016;44:1–15.

    Article  CAS  Google Scholar 

  • Modjtahedi N, Hangen E, Gonin P, Kroemer G. Metabolic epistasis among apoptosis-inducing factor and the mitochondrial import factor CHCHD4. Cell Cycle. 2015;14:2743–7. doi:10.1080/15384101.2015.1068477.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Modjtahedi N, Tokatlidis K, Dessen P, Kroemer G. Mitochondrial proteins containing coiled-coil-helix-coiled-coil-helix (CHCH) domains in health and disease. Trends Biochem Sci. 2016;41:245–60. doi:10.1016/j.tibs.2015.12.004.

    Article  PubMed  CAS  Google Scholar 

  • Pospisilik JA, Knauf C, Joza N, Benit P, Orthofer M, Cani PD, et al. Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell. 2007;131:476–91. doi:10.1016/j.cell.2007.08.047.

    Article  PubMed  CAS  Google Scholar 

  • Rinaldi C, Grunseich C, Sevrioukova IF, Schindler A, Horkayne-Szakaly I, Lamperti C, et al. Cowchock syndrome is associated with a mutation in apoptosis-inducing factor. Am J Hum Genet. 2012;91:1095–102. doi:10.1016/j.ajhg.2012.10.008.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Scott AJ, Wilkinson AS, Wilkinson JC. Basal metabolic state governs AIF-dependent growth support in pancreatic cancer cells. BMC Cancer. 2016;16:286–300. doi:10.1186/s12885-016-2320-3.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sevrioukova IF. Apoptosis-inducing factor: structure, function, and redox regulation. Antioxid Redox Signal. 2011;14:2545–79. doi:10.1089/ars.2010.3445.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sevrioukova IF. Structure/function relations in AIFM1 variants associated with neurodegenerative disorders. J Mol Biol. 2016. doi:10.1016/j.jmb.2016.05.004.

    Article  PubMed  Google Scholar 

  • Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 1999;397:441–6. doi:10.1038/17135.

    Article  PubMed  CAS  Google Scholar 

  • Zong L, Guan J, Ealy M, Zhang Q, Wang D, Wang H, et al. Mutations in apoptosis-inducing factor cause X-linked recessive auditory neuropathy spectrum disorder. J Med Genet. 2015;52:523–31. doi:10.1136/jmedgenet-2014-102961.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nazanine Modjtahedi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Modjtahedi, N., Kroemer, G. (2018). AIFM1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_174

Download citation

Publish with us

Policies and ethics