Eps8 (Epidermal Growth Factor Receptor Pathway Substrate 8)
Eps8 (EGFR pathway substrate #8) is an actin-binding and signaling molecule with a molecular weight of 97KDa encoded by a gene comprising 21 exons located on the human chromosome 12p12. It was originally identified through an expression cloning approach designed to isolate intracellular substrates for the tyrosine kinase of the Epidermal Growth Factor Receptor (EGFR) (Fazioli et al. 1993). Eps8 is efficiently phosphorylated on tyrosine residues by a variety of both receptor and non-receptor tyrosine kinases (Fazioli et al. 1993). Following stimulation with neurotrophic factor BDNF, which critically controls growth and differentiation processes in the brain during development, through the activation of Trk tyrosine kinase receptors, Eps8 can also be phosphorylated, in a MAPK-dependent manner, on serine and threonine residues. Notably, while the...
This study was supported by the NIH Cell Migration Consortium grant U54 GM064346 from the National Institute of General Medical Sciences (NIGMS) to DH and NV; from the Associazione Italiana per la Ricerca sul Cancro (AIRC), the Italian Ministries of Education-University-Research (MIUR-PRIN) and of Health, AICR (International Association For Cancer Research – AICR), and from IFOM Foundation to GS; FM is supported by a fellowship from Fondazione Italiana Ricerca sul Cancro (FIRC).