FGR (Gene Name)
FGR is a cytoplasmic protein-tyrosine kinase belonging to the SRC family of protein tyrosine kinases. This kinase was originally described in the context of a feline sarcoma virus isolated from a spontaneous sarcoma of a domestic house cat and named GR-FeSV (Gardner-Rasheed feline sarcoma virus), whose primary translation product was shown to be a 70 kDa gag-fgr fusion peptide (Rasheed et al. 1982). Later studies identified this peptide as having a portion with amino acid homology with actin and another one related to a tyrosine kinase homologous to gene sequences present in the DNA of diverse invertebrate species (Naharro et al. 1983, 1984). FGR is expressed in human and murine hematopoietic cells including granulocytes, monocytes/macrophages, natural killer cells, platelets, and erythrocytes (Berton 2006; Lowell 2004). Its function has been mainly characterized in innate immunity cells and...
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- Naharro G, Tronick SR, Rasheed S, Gardner MB, Aaronson SA, Robbins KC. Molecular cloning of integrated Gardner-Rasheed feline sarcoma virus: genetic structure of its cell-derived sequence differs from that of other tyrosine kinase-coding onc genes. J Virol. 1983;47:611–9.PubMedPubMedCentralGoogle Scholar