Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

NFAT

  • Rachel Y. Ames
  • Rut Valdor
  • Brian T. Abe
  • Fernando Macian
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_141

Synonyms

 NFATc1 (Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1; NFAT2; NFATc, NFAT cytoplasmic);  NFATc2 (Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2; NFAT1; NFATp, NFAT preexisting);  NFATc3 (Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3; NFAT4; NFATx);  NFATc4 (Nuclear factor of activated T-cells cytoplasmic calcineurin dependent 4, NFAT3);  NFAT5 (Nuclear factor of activated T-cells 5; TonEBP, Tonicity-responsive enhancer binding protein; OREBP, Osmotic response element-binding protein)

Historical Background

The gene encoding for the first nuclear factor of activated T cells (NFAT) protein was cloned more than 20 years ago and termed NFATp, as it was shown to be “preexistent” in the cytosol of resting T cells. In activated T cells, NFATp interacted with the transcription factors Fos and Jun in the nucleus to induce the expression of interleukin (IL-) 2 (Jain et al. 1993). Soon after, new members of the...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Rachel Y. Ames
    • 1
  • Rut Valdor
    • 2
  • Brian T. Abe
    • 3
  • Fernando Macian
    • 1
  1. 1.Department of PathologyAlbert Einstein College of MedicineBronxUSA
  2. 2.Department of Human Anatomy and PsychobiologyUniversity of Murcia School of Medicine and Instituto Murciano de Investigación BiosanitariaMurciaSpain
  3. 3.Scripps Translational Science InstituteLa JollaUSA