Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Rin (Ras-Like Protein in Neurons)

  • Jennifer L. Rudolph
  • Douglas A. AndresEmail author
  • Weikang Cai
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_122


Historical Background

Ras superfamily small GTP (guanosine triphosphate)-binding proteins function as molecular switches, responding to extra- and intracellular stimuli to control the activity of diverse signaling cascades. To date, over 150 different small GTPases have been identified and are classified into six distinct subfamilies – Ras (Rat sarcoma), Rho (Ras homolog gene family), Rab (Ras-related GTP- binding protein), ARF (ADP- ribosylation factor), Ran (Ras-related nuclear protein), and RGK (Rad/Gem/Kir family) – based upon both sequence homology and the regulation of common cellular functions (Colicelli 2004). Rin (Ras-like protein in neurons), along with Rit (Ras-like protein in many tissues) and Drosophila Ric (Ras-related protein which interacted with calmodulin), comprise the Rit subfamily of Ras-related small GTPases (Lee et al. 1996). Rin is expressed exclusively within neurons, including RGCs (retinal ganglion cells)...

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This work was supported by Public Health Service grant NS045103 from the National Institute of Neurological Disorders and Stroke and 14-1 from the Kentucky Spinal Cord and Head Injury Research Trust.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Jennifer L. Rudolph
    • 1
  • Douglas A. Andres
    • 2
    Email author
  • Weikang Cai
    • 2
  1. 1.Department of ChemistryMercer University College of Liberal ArtsMaconUSA
  2. 2.Department of Molecular and Cellular BiochemistryUniversity of Kentucky College of MedicineLexingtonUSA