Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

CD44

  • Niharika Swain
  • Samapika Routray
  • Rashmi Maruti Hosalkar
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101999

Synonyms

Historical Background

CD44 is a transmembrane glycoprotein and also major hyaluronan receptor, mediating cell responses to the extracellular microenvironment. In 1980s, it was first described as a surface molecule restricted to few immune cells like lymphocytes, thymocytes, and granulocytes (Dalchau et al. 1980), but later it was recognized as a novel human erythrocyte cell surface antigen, lymphocyte homing receptor, and leukocyte surface glycoprotein (Stefanová et al. 1989). Today, CD44 is being described as an adhesion molecule expressed in various cell types which includes both epithelial cells (even in keratinocytes) and connective tissue cells (endothelial cells, fibroblasts and leukocytes). It participates in a...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Niharika Swain
    • 1
  • Samapika Routray
    • 2
  • Rashmi Maruti Hosalkar
    • 3
    • 4
  1. 1.MGM Dental College and HospitalNavi MumbaiIndia
  2. 2.Department of Dental SurgeryAll India Institute of Medical SciencesBhubaneswarIndia
  3. 3.Indian Association of Oral and Maxillofacial PathologistsMumbaiIndia
  4. 4.Maharashtra State Dental CouncilMumbaiIndia