Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Natriuretic Peptide Receptor Type C (NPRC)

  • Nicolás M. KouyoumdzianEmail author
  • Natalia L. Rukavina Mikusic
  • Hyun J. Lee
  • Belisario E. Fernández
  • Marcelo R. Choi
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101995


Historical Background

The natriuretic system constitutes a family of cardiac- and vascular-derived hormones named Atrial Natriuretic Peptide (ANP), Brain Natriuretic Peptide (BNP), C-type Natriuretic Peptide (CNP), and Urodilatin (URO), which play an essential role on the regulation of blood pressure, intravascular volume, and electrolyte homeostasis in all mammals. Binding of natriuretic peptides (NPs) to either Natriuretic Peptide Receptor Type A (NPRA) or type B (NPRB) leads to activation of the particulate guanylate cyclase (pGC) catalytic domain which generates cGMP-dependent second messenger signaling cascade, mediating most of the biological actions of these peptides (Anand-Srivastava and Trachte 1993). NPs bind also to NPRC, which is considered a clearance receptor responsible for receptor-mediated degradation of these peptides. In addition, recent studies have revealed...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Nicolás M. Kouyoumdzian
    • 1
    Email author
  • Natalia L. Rukavina Mikusic
    • 1
  • Hyun J. Lee
    • 2
  • Belisario E. Fernández
    • 1
  • Marcelo R. Choi
    • 1
    • 2
  1. 1.Instituto de Investigaciones Cardiológicas “Prof. Dr. Alberto C. Taquini”, ININCA, UBA-CONICETBuenos AiresArgentina
  2. 2.Cátedra de Anatomía e Histología, Departamento de Ciencias Biológicas, Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresBuenos AiresArgentina