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STAT6

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References

  • Ansel KM, Djuretic I, Tanasa B, Rao A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol. 2006;24:607–56.

    Article  PubMed  CAS  Google Scholar 

  • Boothby M, Gravallese E, Liou HC, Glimcher LH. A DNA-binding protein regulated by Il-4 and by differentiation in B-cells. Science. 1988;242:1559–62.

    Article  PubMed  CAS  Google Scholar 

  • Chen HC, Reich NC. Live cell imaging reveals continuous STAT6 nuclear trafficking. J Immunol. 2010;185:64–70.

    Article  PubMed  CAS  Google Scholar 

  • Darcan-Nicolaisen Y, Meinicke H, Fels G, Hegend O, Haberland A, Kuhl A, Loddenkemper C, Witzenrath M, Kube S, Henke W, Hamelmann E. Small interfering RNA against transcription factor STAT6 inhibits allergic airway inflammation and hyperreactivity in mice. J Immunol. 2009;182:7501–8.

    Article  PubMed  CAS  Google Scholar 

  • Doyle LA, Tao D, Marino-Enriquez A. STAT6 is amplified in a subset of dedifferentiated liposarcoma. Mod Pathol. 2014;27:1231–7.

    Article  PubMed  CAS  Google Scholar 

  • Goenka S, Kaplan MH. Transcriptional regulation by STAT6. Immunol Res. 2011;50:87–96.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hanson EM, Dickensheets H, Qu CK, Donnelly RP, Keegan AD. Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome. J Biol Chem. 2003;278:3903–11.

    Article  PubMed  CAS  Google Scholar 

  • Hebenstreit D, Wirnsberger G, Horejs-Hoeck J, Duschl A. Signaling mechanisms, interaction partners, and target genes of STAT6. Cytokine Growth Factor Rev. 2006;17:173–88.

    Article  PubMed  CAS  Google Scholar 

  • Hoey T, Schindler U. STAT structure and function in signaling. Curr Opin Genet Dev. 1998;8:582–7.

    Article  PubMed  CAS  Google Scholar 

  • Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, Mcknight SL. An interleukin-4-induced transcription factor: IL-4 Stat. Science. 1994;265:1701–6.

    Article  PubMed  CAS  Google Scholar 

  • Iciek LA, Delphin SA, Stavnezer J. CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction. J Immunol. 1997;158:4769–79.

    PubMed  CAS  Google Scholar 

  • Kim BE, Leung DY, Boguniewicz M, Howell MD. Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin Immunol. 2008;126:332–7.

    Article  PubMed  CAS  Google Scholar 

  • Levitt RC, Mclane MP, Macdonald D, Ferrante V, Weiss C, Zhou T, Holroyd KJ, Nicolaides NC. IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders. J Allergy Clin Immunol. 1999;103:S485–91.

    Article  PubMed  CAS  Google Scholar 

  • Levy DE, Darnell JE. STATs: transcriptional control and biological impact. Nat Rev Mol Cell Biol. 2002a;3:651–62.

    Article  PubMed  CAS  Google Scholar 

  • Levy DE, Darnell Jr JE. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol. 2002b;3:651–62.

    Article  PubMed  CAS  Google Scholar 

  • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol. 2009;27:451–83.

    Article  PubMed  CAS  Google Scholar 

  • Mcdonald C, Reich NC. Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J Interf Cytokine Res. 1999;19:711–22.

    Article  CAS  Google Scholar 

  • Mizel SB. The interleukins. FASEB J. 1989;3:2379–88.

    Article  PubMed  CAS  Google Scholar 

  • Mullings RE, Wilson SJ, Puddicombe SM, Lordan JL, Bucchieri F, Djukanovic R, Howarth PH, Harper S, Holgate ST, Davies DE. Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium. J Allergy Clin Immunol. 2001;108:832–8.

    Article  PubMed  CAS  Google Scholar 

  • Patel BK, Pierce JH, Larochelle WJ. Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6. Proc Natl Acad Sci U S A. 1998;95:172–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pesu M, Aittomaki S, Valineva T, Silvennoinen O. PU.1 is required for transcriptional activation of the Stat6 response element in the Igepsilon promoter. Eur J Immunol. 2003;33:1727–35.

    Article  PubMed  CAS  Google Scholar 

  • Reich NC. STATs get their move on. JAKSTAT. 2013;2:e27080.

    PubMed  PubMed Central  Google Scholar 

  • Schindler U, Wu P, Rothe M, Brasseur M, Mcknight SL. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity. 1995;2:689–97.

    Article  PubMed  CAS  Google Scholar 

  • Sehra S, Yao Y, Howell MD, Nguyen ET, Kansas GS, Leung DY, Travers JB, Kaplan MH. IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. J Immunol. 2010;184:3186–90.

    Article  PubMed  CAS  Google Scholar 

  • Shankaranarayanan P, Chaitidis P, Kuhn H, Nigam S. Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. J Biol Chem. 2001;276:42753–60.

    Article  PubMed  Google Scholar 

  • Sherman MA, Secor VH, Brown MA. IL-4 preferentially activates a novel STAT6 isoform in mast cells. J Immunol. 1999;162:2703–8.

    PubMed  CAS  Google Scholar 

  • Shimoda K, Van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DA, Doherty PC, Grosveld G, Paul WE, Ihle JN. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 1996;380:630–3.

    Article  PubMed  CAS  Google Scholar 

  • Takeda K, Kamanaka M, Tanaka T, Kishimoto T, Akira S. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol. 1996a;157:3220–2.

    PubMed  CAS  Google Scholar 

  • Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S. Essential role of Stat6 in IL-4 signalling. Nature. 1996b;380:627–30.

    Article  PubMed  CAS  Google Scholar 

  • Tang X, Marciano DL, Leeman SE, Amar S. LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Proc Natl Acad Sci U S A. 2005;102:5132–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Walford HH, Doherty TA. STAT6 and lung inflammation. JAKSTAT. 2013;2:e25301.

    PubMed  PubMed Central  Google Scholar 

  • Wang Y, Malabarba MG, Nagy ZS, Kirken RA. Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function. J Biol Chem. 2004;279:25196–203.

    Article  PubMed  CAS  Google Scholar 

  • Wang Y, Li Y, Shan J, Fixman E, Mccusker C. Effective treatment of experimental ragweed-induced asthma with STAT-6-IP, a topically delivered cell-penetrating peptide. Clin Exp Allergy. 2011;41:1622–30.

    Article  PubMed  CAS  Google Scholar 

  • Wang C, Zhu C, Wei F, Zhang L, Mo X, Feng Y, Xu J, Yuan Z, Robertson E, Cai Q. Constitutive activation of interleukin-13/STAT6 contributes to Kaposi’s sarcoma-associated herpesvirus-related primary effusion lymphoma cell proliferation and survival. J Virol. 2015;89:10416–26.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wurster AL, Tanaka T, Grusby MJ. The biology of Stat4 and Stat6. Oncogene. 2000;19:2577–84.

    Article  PubMed  CAS  Google Scholar 

  • Yao Y, Li W, Kaplan MH, Chang CH. Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J Exp Med. 2005;201:1899–903.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhuang S. Regulation of STAT signaling by acetylation. Cell Signal. 2013;25:1924–31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Correspondence to Venkateswarlu Kanamarlapudi .

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Skalkoyannis, B., Kanamarlapudi, V. (2018). STAT6. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101988

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