Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TNFSFS12)

  • Luis M. Blanco-Colio
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101976

Synonyms

Historical Background

Tumor necrosis factor superfamily (TNFSF) members are implicated in numerous cellular processes such as proliferation, migration, inflammation, and cell death. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) was first identified as a novel member of the tumor necrosis factor superfamily of proteins displaying pro-apoptotic activity on interferon gamma (INF-γ)-treated human HT-29 colon carcinoma cells (Chicheportiche et al. 1997). The human TWEAK gene is located at chromosomal position 17p13.1 and encodes a 249-amino acid (aa) type II transmembrane-bound protein (mTWEAK). mTWEAK comprises an intracellular N-terminal domain, which contains a potential protein kinase C phosphorylation site, a transmembrane domain, and an extracellular TNF homology domain (THD) containing the receptor-binding site (Chicheportiche et al. 1997) (Fig. 1). mTWEAK is...
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Vascular Research LabFIIS-Fundación Jiménez DíazMadridSpain
  2. 2.Biomedical Research Center in Cardiovascular MedicineCIBERCVSpain