Historical Background
“Colony-stimulating factors” were first described in the 1960s as soluble agents that mediated the growth of colonies in soft agar from bone marrow cells. One of these was called granulocyte colony-stimulating factor (G-CSF) due to its propensity to induce colonies composed of neutrophilic granulocytes. The purification, sequencing, and cloning of this factor led to the production of recombinant G-CSF that facilitated the identification of a specific cell-surface receptor through expression library screening (Fukunaga et al. 1990). This protein was named granulocyte colony-stimulating factor receptor (G-CSFR), although the gene has now been officially designated colony-stimulating factor 3 receptor (CSF3R).
G-CSFR Evolution and Structure
G-CSFR is a member of the class I cytokine receptor superfamily. These molecules emerged early in...
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Donadieu J, Leblanc T, Bader Meunier B, Barkaoui M, Fenneteau O, Bertrand Y, et al. Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. Experience of the French Severe Chronic Neutropenia Study Group. Haematologica. 2005;90:45–53.
Dong F, Brynes RK, Tidow N, Welte K, Lowenberg B. Touw IP Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N Engl J Med. 1995a;333:487–93.
Dong F, van Paassen M, van Buitenen C, Hoefsloot LH, Löwenberg B, Touw IP. A point mutation in the granulocyte colony-stimulating factor receptor (G-CSF-R) gene in a case of acute myeloid leukemia results in the overexpression of a novel G-CSF-R isoform. Blood. 1995b;85:902–11.
Fukunaga R, Ishizaka Ikeda E, Seto Y, Nagata S. Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell. 1990;61:341–50.
Greenbaum AM, Link DC. Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization. Leukemia. 2011;25:211–7.
Klocke R, Kuhlmann MT, Scobioala S, Schabitz WR, Nikol S. Granulocyte colony-stimulating factor (G-CSF) for cardio- and cerebrovascular regenerative applications. Curr Med Chem. 2008;15:968–77.
Kumar J, Fraser FW, Riley C, Ahmed N, McCulloch DR, Ward AC. Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/Signal transducer and activator of transcription 3 in ovarian cancer. Br J Cancer. 2014;110:133–45.
Liongue C, Ward AC. Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy. Front Oncol. 2014;4:93.
Liongue C, Hall C, O’Connell B, Crozier P, Ward AC. Zebrafish granulocyte colony-stimulating factor receptor signalling promotes myelopoiesis and myeloid cell migration. Blood. 2009a;113:2535–46.
Liongue C, Wright C, Russell AP, Ward AC. Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more. Int J Biochem Cell Biol. 2009b;41:2372–5.
Liongue C, Sertori R, Ward AC. Evolution of cytokine receptor signaling. J Immunol. 2016;197:11–8.
Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC. Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity. 1996;5:491–501.
Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, et al. Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med. 2013;368:1781–90.
Palande K, Meenhuis A, Jevdjovic T, Touw IP. Scratching the surface: signaling and routing dynamics of the CSF3 receptor. Front Biosci (Landmark Ed). 2013;18:91–105.
Pitzer C, Kruger C, Plaas C, Kirsch F, Dittgen T, Muller R, et al. Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis. Brain. 2008;131:3335–47.
Sung L, Dror Y. Clinical applications of granulocyte-colony stimulating factor. Front Biosci. 2007;12:1988–2002.
Touw IP, Beekman R. Severe congenital neutropenia and chronic neutrophilic leukemia: an intriguing molecular connection unveiled by oncogenic mutations in CSF3R. Haematologica. 2013;98:1490–2.
Touw IP, van de Geijn GJ. Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders. Front Biosci. 2007;12:800–15.
Ward AC, van Aesch YM, Gits J, Schelen AM, de Koning JP, van Leeuwen D, et al. Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment. J Exp Med. 1999;190:497–507.
Wolfler A, Erkeland SJ, Bodner C, Valkhof M, Renner W, Leitner C, et al. A functional single-nucleotide polymorphism of the G-CSF receptor gene predisposes individuals to high-risk myelodysplastic syndrome. Blood. 2005;105:3731–6.
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Liongue, C., Ward, A.C. (2018). GCSF Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101956
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101956
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