Historical Background: Cyclin-Dependent Kinase 4 (CDK4) in Cell Cycle Control and Regulation
The mammalian cell cycle is typically divided into four phases, G1, S, G2, and M, and within the last two decades, there have been a series of discoveries that have provided us with a better understanding of the control mechanisms that regulate cell cycle progression. It is apparent that the order and timing of the cell cycle is critical for accurate transmission of genetic information, and consequently, a number of biochemical pathways have evolved to ensure that initiation of a particular cell cycle event is dependent on the accurate completion of another. These biochemical pathways have been termed “checkpoints.”
Mitogenic growth factors bind to their cognate receptors and initiate a cascade of events that culminate in the expression and assembly of different kinase holoenzymes composed of a regulatory...
This work was supported by grants from the NIH (P01CA-130821), (NIH-RO1-CA-158209) to EPR.
Conflict of Interest Statement
The authors declare no conflicts of interest with respect to the authorship and publication of this article.