Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

TRPM1

  • Tetsuo Kon
  • Takahisa Furukawa
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101948

Synonyms

Historical Background

The transient receptor potential (TRP) channels play a diverse range of essential roles in the sensory systems of various species, including both invertebrates and vertebrates. The TRP channel was first identified as a molecule required for proper light response in Drosophila melanogaster. Thereafter, a series of TRP family proteins have been identified. Recently, TRPM1, the founding member of the melanoma-related transient receptor potential (TRPM) subfamily, was shown to be required for the photoresponse in mouse retinal ON bipolar cells. It further proved that TRPM1 is a component of the transduction cation channel negatively regulated by the metabotropic glutamate receptor 6 (mGluR6) cascade in ON bipolar cells through a reconstitution experiment using CHO cells expressing TRPM1, mGluR6, and Goα. In addition to the function of visual...

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Notes

Acknowledgments

TRPM1-related work conducted in the authors’ laboratory is supported by the CREST from Japan Science and Technology Agency, Grant-in-Aid for Scientific Research (B), Takeda Science Foundation, Koyanagi Foundation, and Terumo Foundation for Life Science and Arts Life Science support program.

References

  1. Audo I, Robson AG, Holder GE, Moore AT. The negative ERG: clinical phenotypes and disease mechanisms of inner retinal dysfunction. Surv Ophthalmol. 2008;53:16–40.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Bellone RR, Brooks SA, Sandmeyer L, Murphy BA, Forsyth G, Archer S, Bailey E, Grahn B. Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus). Genetics. 2008;179:1861–70.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Cao Y, Posokhova E, Martemyanov KA. TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner. J Neurosci. 2011;31:11521–6.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Dhingra A, Fina ME, Neinstein A, Ramsey DJ, Xu Y, Fishman GA, Alexander KR, Qian H, Peachey NS, Gregg RG, Vardi N. Autoantibodies in melanoma-associated retinopathy target TRPM1 cation channels of retinal ON bipolar cells. J Neurosci. 2011;31:3962–7.PubMedPubMedCentralCrossRefGoogle Scholar
  5. Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW. Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res. 1998;58:1515–20.PubMedPubMedCentralGoogle Scholar
  6. Iwakabe H, Katsuura G, Ishibashi C, Nakanishi S. Impairment of pupillary responses and optokinetic nystagmus in the mGluR6-deficient mouse. Neuropharmacology. 1997;36:135–43.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Koike C, Sanuki R, Miyata K, Koyasu T, Miyoshi T, Sawai H, Kondo M, Usukura J, Furukawa T. The functional analysis of TRPM1 in retinal bipolar cells. Neurosci Res. 2007;58:S41.CrossRefGoogle Scholar
  8. Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, Furukawa T. TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A. 2010a;107:332–7.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Koike C, Numata T, Ueda H, Mori Y, Furukawa T. TRPM1: A vertebrate TRP channel responsible for retinal ON bipolar function. Cell Calcium. 2010b;48:95–101.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T. Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction. PLoS One. 2011;6:e19911.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Li Z, Sergouniotis PI, Michaelides M, Mackay DS, Wright GA, Devery S, Moore AT, Holder GE, Robson AG, Webster AR. Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans. Am J Hum Genet. 2009;85:711–9.PubMedPubMedCentralCrossRefGoogle Scholar
  12. Masu M, Iwakabe H, Tagawa Y, Miyoshi T, Yamashita M, Fukuda Y, Sasaki H, Hiroi K, Nakamura Y, Shigemoto R, Takada M, Nakamura K, Nakao K, Katsuki M, Nakanishi S. Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell. 1995;80:757–65.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Montell C, Jones K, Hafen E, Rubin G. Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science. 1985;230:1040–3.PubMedPubMedCentralCrossRefGoogle Scholar
  14. Morigiwa K, Vardi N. Differential expression of ionotropic glutamate receptor subunits in the outer retina. J Comp Neurol. 1999;405:173–84.PubMedPubMedCentralCrossRefGoogle Scholar
  15. Nakamura M, Sanuki R, Yasuma TR, Onishi A, Nishiguchi KM, Koike C, Kadowaki M, Kondo M, Miyake Y, Furukawa T. TRPM1 mutations are associated with the complete form of congenital stationary night blindness. Mol Vis. 2010;16:425–37.PubMedPubMedCentralGoogle Scholar
  16. Nakanishi S, Nakajima Y, Masu M, Ueda Y, Nakahara K, Watanabe D, Yamaguchi S, Kawabata S, Okada M. Glutamate receptors: brain function and signal transduction. Brain Res Brain Res Rev. 1998;26:230–5.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Nawy S. The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells. J Neurosci. 1999;19:2938–44.PubMedPubMedCentralCrossRefGoogle Scholar
  18. Neuillé M, Morgans CW, Cao Y, Orhan E, Michiels C, Sahel JA, Audo I, Duvoisin RM, Martemyanov KA, Zeitz C. LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation. Eur J Neurosci. 2015;42:1966–75.PubMedPubMedCentralCrossRefGoogle Scholar
  19. Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE. TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal. 2009;2:ra21.PubMedPubMedCentralGoogle Scholar
  20. Orlandi C, Cao Y, Martemyanov KA. Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling Cascade in retina ON-bipolar neurons. Invest Ophthalmol Vis Sci. 2013;54:7153–61.PubMedPubMedCentralCrossRefGoogle Scholar
  21. Pearring JN, Bojang P, Shen Y, Koike C, Furukawa T, Nawy S, Gregg RG. A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites. J Neurosci. 2011;31:10060–6.PubMedPubMedCentralCrossRefGoogle Scholar
  22. Shen Y, Rampino MA, Carroll RC, Nawy S. G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer. Proc Natl Acad Sci U S A. 2012;109:8752–7.PubMedPubMedCentralCrossRefGoogle Scholar
  23. Shiells RA, Falk G, Naghshineh S. Action of glutamate and aspartate analogues on rod horizontal and bipolar cells. Nature. 1981;294:592–4.PubMedPubMedCentralCrossRefGoogle Scholar
  24. Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol. 2013;30:2725–9.PubMedPubMedCentralCrossRefGoogle Scholar
  25. Tsuruda PR, Julius D, Minor DL. Coiled coils direct assembly of a cold-activated TRP channel. Neuron. 2006;51:201–12.PubMedPubMedCentralCrossRefGoogle Scholar
  26. Venkatachalam K, Montell C. TRP channels. Annu Rev Biochem. 2007;76:387–417.PubMedPubMedCentralCrossRefGoogle Scholar
  27. Xu Y, Orlandi C, Cao Y, Yang S, Choi CI, Pagadala V, Birnbaumer L, Martemyanov KA, Vardi N. The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go. The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go. Sci Rep. 2016;6:20940.Google Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Laboratory for Molecular and Developmental Biology, Institute for Protein ResearchOsaka UniversityOsakaJapan