Transient Receptor Potential Cation Channel, Subfamily C, Member 2, Pseudogene
The transient receptor potential (TRP) channels were first detected in a Drosophila photoreceptor mutant, where continuous light resulted in a transient voltage response. Further studies revealed that the channels had a profound selectivity for calcium. As the light response in the photoreceptors is evoked by activation of a G protein and phospholipase C, it was speculated that vertebrate homologs of the channels could exist and that these channels could participate in, e.g., receptor- and store-operated calcium entry in response to agonist stimulations. The first vertebrate homologs of TRP were subsequently detected in 1995, and further intense studies resulted in the detection of a total of 29 vertebrate (28 in humans) TRP isoforms. Of these isoforms, the canonical transient receptor potential channel (TRPC) subfamily is the isoform that has the highest degree of homology to the DrosophilaTRP channels. The TRPC channels are nonselective cation...
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