Reference work entry
Background and Discovery of WISP1
Wnt-1 inducible signaling pathway protein 1 (WISP1) is an exciting target for the development of new treatments against acute and chronic disorders that may involve cellular metabolism as well as the nervous, musculoskeletal, cardiac, pulmonary, and vascular systems (Maiese 2014) (Fig. 1). WISP1 also is known as CCN4 and is a member of the CCN family of proteins. The CCN family of proteins consists of six secreted extracellular matrix-associated proteins and is defined by the first three members of the family that include cysteine-rich protein 61, connective tissue growth factor, and nephroblastoma overexpressed gene. Each family member has four cysteine-rich modular domains that include insulin-like growth factor-binding...
This research was supported by the following grants to Kenneth Maiese: American Diabetes Association, American Heart Association, NIH NIEHS, NIH NIA, NIH NINDS, and NIH ARRA.
- Maeda A, Ono M, Holmbeck K, Li L, Kilts TM, Kram V, Noonan ML, Yoshioka Y, McNerny E, Tantillo M, Kohn D, Lyons KM, Robey PG, Young MF. WNT1 induced secreted protein-1 (WISP1): a novel regulator of bone turnover and Wnt signaling. J Biol Chem. 2015;290(22):14004–18.PubMedPubMedCentralCrossRefGoogle Scholar
- Murahovschi V, Pivovarova O, Ilkavets I, Dmitrieva RM, Docke S, Keyhani-Nejad F, Gogebakan O, Osterhoff M, Kemper M, Hornemann S, Markova M, Kloting N, Stockmann M, Weickert MO, Lamounier-Zepter V, Neuhaus P, Konradi A, Dooley S, von Loeffelholz C, Bluher M, Pfeiffer AF, Rudovich N. WISP1 is a novel adipokine linked to inflammation in obesity. Diabetes. 2015;64(3):856–66.PubMedCrossRefGoogle Scholar
- Ono M, Inkson CA, Sonn R, Kilts TM, de Castro LF, Maeda A, Fisher LW, Robey PG, Berendsen AD, Li L, McCartney-Francis N, Brown AC, Crawford NP, Molinolo A, Jain A, Fedarko NS, Young MF. WISP1/CCN4: a potential target for inhibiting prostate cancer growth and spread to bone. PLoS One. 2013;8(8):e71709.PubMedPubMedCentralCrossRefGoogle Scholar
- Sahin Ersoy G, Altun Ensari T, Subas S, Giray B, Simsek EE, Cevik O. WISP1 is a novel adipokine linked to metabolic parameters in gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2016;8:1–5.Google Scholar
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