Transient Receptor Potential Cation Channel Subfamily C Member 5
Reference work entry
TRPC5 is a member of the canonical family of transient receptor potential (TRP) channels, forming a subgroup along with TRPC1 and TRPC4. TRPC5 has been cloned from the mouse (Okada et al. 1998; Philipp et al. 1998), rabbit (Philipp et al. 1998), and humans, lying in the Xq23 region of the latter, a region that contains loci for nonsyndromic mental retardation and two genes implicated in X-linked disorders. The TRPC5 protein forms homomers and heteromers with TRPC1, TRPC3, TRPC4, and TRPC6 (Strubing et al. 2001). Like other members of the TRPC family, TRPC5 is a nonselective cationic channel that permits the flow of calcium, sodium, cesium, and potassium ions, although with greater selectivity for Ca 2+. Cation selectivity varies in the literature, from P Ca 2+/P Na + = 14.3 (Okada et al. 1998) to P Ca 2+/P Na + = 1.79 (Schaefer et al. 2000). When...
- Lembrechts R, Brouns I, Schnorbusch K, Pintelon I, Timmermans JP, Adriaensen D. Neuroepithelial bodies as mechanotransducers in the intrapulmonary airway epithelium: involvement of TRPC5. Am J Respir Cell Mol Biol. 2012;47:315–23. https://doi.org/10.1165/rcmb.2012-0068OC.CrossRefPubMedPubMedCentralGoogle Scholar
- Okada T, Shimizu S, Wakamori M, Maeda A, Kurosaki T, Takada N, et al. Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. JBiolChem. 1998;273:10279–87.Google Scholar
- Ordaz B, Tang J, Xiao R, Salgado A, Sampieri A, Zhu MX, et al. Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation. JBiolChem. 2005;280:30788–96.Google Scholar
- Schaefer M, Plant TD, Obukhov AG, Hofmann T, Gudermann T, Schultz G. Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. JBiolChem. 2000;275:17517–26.Google Scholar
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